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Title: Maternal exposure to metals—Concentrations and predictors of exposure

A variety of metals are important for biological function but have also been shown to impact health at elevated concentrations, whereas others have no known biological function. Pregnant women are a vulnerable population and measures to reduce exposure in this group are important. We undertook a study of maternal exposure to the metals, aluminium, arsenic, copper, cobalt, chromium, lithium, manganese, nickel, selenium, tin, uranium and zinc in 173 participants across Western Australia. Each participant provided a whole blood and urine sample, as well as drinking water, residential soil and dust samples and completed a questionnaire. In general the concentrations of metals in all samples were low with the notable exception of uranium (blood U mean 0.07 µg/L, range <0.01–0.25 µg/L; urinary U mean 0.018 µg/g creatinine, range <0.01–0.199 µg/g creatinine). Factors that influenced biological concentrations were consumption of fish which increased urinary arsenic concentrations, hobbies (including mechanics and welding) which increased blood manganese concentrations and iron/folic acid supplement use which was associated with decreased concentrations of aluminium and nickel in urine and manganese in blood. Environmental concentrations of aluminium, copper and lithium were found to influence biological concentrations, but this was not the case for other environmental metals concentrations. Furthermore » work is underway to explore the influence of diet on biological metals concentrations in more detail. The high concentrations of uranium require further investigation. -- Highlights: • High concentrations of uranium with respect to international literature. • Environmental concentrations of Al, Cu and Li influenced urinary concentrations. • Exposure to mechanics/welding hobbies increased blood Mn concentrations. • Iron/Folic acid supplements reduced biological concentrations of Al, Ni and Mn.« less
Authors:
 [1] ; ; ;  [1] ;  [2] ;  [3] ;  [4]
  1. Centre for Ecosystem Management, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA 6027 (Australia)
  2. School Population Health, The University of Western Australia, 35 Stirling Highway Crawley, WA 6009 (Australia)
  3. ChemCentre, PO Box 1250, Bentley, WA 6983 (Australia)
  4. Department of Community Medicine, University of Tromsø, N-9037 Tromsø (Norway)
Publication Date:
OSTI Identifier:
22246953
Resource Type:
Journal Article
Resource Relation:
Journal Name: Environmental Research; Journal Volume: 126; Other Information: Copyright (c) 2013 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
54 ENVIRONMENTAL SCIENCES; ABUNDANCE; ALUMINIUM; ARSENIC; BIOLOGICAL FUNCTIONS; BIOLOGICAL MARKERS; BLOOD; CHROMIUM; COBALT; CONCENTRATION RATIO; COPPER; CREATININE; DIET; DRINKING WATER; FOLIC ACID; IRON; LITHIUM; MANGANESE; NICKEL; SELENIUM; TIN; URANIUM; URINE; WESTERN AUSTRALIA; ZINC