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Title: Farnesoid X receptor up-regulates expression of Lipid transfer inhibitor protein in liver cells and mice

Highlights: •FXR up-regulates apoF. •It binds to ER1 element. •It activates apoF gene promoter. -- Abstract: Apolipoprotein F is a component protein mainly secreted by liver and resides on several lipoprotein classes. It can inhibit lipids transfer between different lipoproteins. FXR is a member of the nuclear receptor superfamily which is also highly expressed in the liver. It modulates bile acids synthesis and lipids metabolism by transcriptional regulation. We aimed to determine whether apoF can be regulated by FXR. The FXR agonist Chenodeoxycholic acid (CDCA) and GW4064 both can activate the expression of apoF in liver cell lines and in C57/BL6 mouse liver. This is dependent on the binding of FXR to the FXR element ER1 (−2904 to −2892 bp) in the apoF gene promoter. Taken together, we have identified apoF as likely another target gene of FXR.
Authors:
 [1] ;  [2] ; ; ; ; ; ;  [1] ;  [1]
  1. Department of Biochemistry and Molecular Biology, College of Basic Medical Science, Third Military Medical University, Chongqing 400038 (China)
  2. Department of Hematology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037 (China)
Publication Date:
OSTI Identifier:
22242210
Resource Type:
Journal Article
Resource Relation:
Journal Name: Biochemical and Biophysical Research Communications; Journal Volume: 441; Journal Issue: 4; Other Information: Copyright (c) 2013 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; BILE ACIDS; BIOSYNTHESIS; BORON PHOSPHIDES; CHOLESTEROL; ESTERS; LIPOPROTEINS; LIVER; LIVER CELLS; METABOLISM; MICE; PETROLEUM RESIDUES; PROMOTERS; RECEPTORS