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Title: CHL1 is involved in human breast tumorigenesis and progression

Highlights: •CHL1 is down-regulation in breast cancer tissues. •Down-regulation of CHL1 is related to high grade. •Overexpression of CHL1 inhibits breast cancer cell proliferation and invasion in vitro. •CHL1 deficiency induces breast cancer cell proliferation and invasion both in vitro and in vivo. -- Abstract: Neural cell adhesion molecules (CAM) play important roles in the development and regeneration of the nervous system. The L1 family of CAMs is comprised of L1, Close Homolog of L1 (CHL1, L1CAM2), NrCAM, and Neurofascin, which are structurally related trans-membrane proteins in vertebrates. Although the L1CAM has been demonstrated play important role in carcinogenesis and progression, the function of CHL1 in human breast cancer is limited. Here, we found that CHL1 is down-regulated in human breast cancer and related to lower grade. Furthermore, overexpression of CHL1 suppresses proliferation and invasion in MDA-MB-231 cells and knockdown of CHL1 expression results in increased proliferation and invasion in MCF7 cells in vitro. Finally, CHL1 deficiency promotes tumor formation in vivo. Our results may provide a strategy for blocking breast carcinogenesis and progression.
Authors:
 [1] ;  [2] ;  [3] ;  [1] ;  [2] ; ;  [4] ;  [2] ;  [1] ;  [2] ;  [1] ;  [2]
  1. Medical Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China)
  2. (China)
  3. Department of Oncology, The General Hospital of Tianjin Medical University, Tianjin (China)
  4. Key Laboratory of Breast Cancer Prevention and Treatment of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China)
Publication Date:
OSTI Identifier:
22242062
Resource Type:
Journal Article
Resource Relation:
Journal Name: Biochemical and Biophysical Research Communications; Journal Volume: 438; Journal Issue: 2; Other Information: Copyright (c) 2013 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ANIMAL TISSUES; CARCINOGENESIS; CELL PROLIFERATION; IN VITRO; IN VIVO; MAMMARY GLANDS; MEMBRANE PROTEINS; NEOPLASMS; NERVOUS SYSTEM; PLANT TISSUES; VERTEBRATES