Long-term Results of Carbon Ion Radiation Therapy for Locally Advanced or Unfavorably Located Choroidal Melanoma: Usefulness of CT-based 2-Port Orthogonal Therapy for Reducing the Incidence of Neovascular Glaucoma

Toyama, Shingo; Tsuji, Hiroshi; Mizoguchi, Nobutaka; Nomiya, Takuma; Kamada, Tadashi; Tokumaru, Sunao; Mizota, Atsushi; Ohnishi, Yoshitaka; Tsujii, Hirohiko

doi:10.1016/J.IJROBP.2012.12.022

Title: Long-term Results of Carbon Ion Radiation Therapy for Locally Advanced or Unfavorably Located Choroidal Melanoma: Usefulness of CT-based 2-Port Orthogonal Therapy for Reducing the Incidence of Neovascular Glaucoma

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Abstract

Purpose: To determine the long-term results of carbon ion radiation therapy (C-ion RT) in patients with choroidal melanoma, and to assess the usefulness of CT-based 2-port irradiation in reducing the risk of neovascular glaucoma (NVG). Methods and Materials: Between January 2001 and February 2012, a total of 116 patients with locally advanced or unfavorably located choroidal melanoma received CT-based C-ion RT. Of these patients, 114 were followed up for more than 6 months and their data analyzed. The numbers of T3 and T2 patients (International Union Against Cancer [UICC], 5th edition) were 106 and 8, respectively. The total dose of C-ion RT varied from 60 to 85 GyE, with each dose given in 5 fractions. Since October 2005, 2-port therapy (51 patients) has been used in an attempt to reduce the risk of NVG. A dose-volume histogram analysis was also performed in 106 patients. Results: The median follow-up was 4.6 years (range, 0.5-10.6 years). The 5-year overall survival, cause-specific survival, local control, distant metastasis-free survival, and eye retention rates were 80.4% (95% confidence interval 89.0%-71.8%), 82.2% (90.6%-73.8%), 92.8% (98.5%-87.1%), 72.1% (81.9%-62.3%), and 92.8% (98.1%-87.5%), respectively. The overall 5-year NVG incidence rate was 35.9% (25.9%-45.9%) and that of 1-port group andmore »« less

Authors:

Toyama, Shingo ^[1]; Tsuji, Hiroshi ^[1]; Mizoguchi, Nobutaka; Nomiya, Takuma; Kamada, Tadashi ^[1]; Tokumaru, Sunao ^[2]; Mizota, Atsushi ^[3]; Ohnishi, Yoshitaka ^[4]; Tsujii, Hirohiko ^[1]

Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba (Japan)
Department of Heavy Particle Therapy and Radiation Oncology, Faculty of Medicine, Saga University, Saga (Japan)
Department of Ophthalmology, Teikyo University School of Medicine, Tokyo (Japan)
Department of Ophthalmology, Wakayama Medical University, Wakayama (Japan)

Publication Date:: Sat Jun 01 00:00:00 EDT 2013

OSTI Identifier:: 22224471

Resource Type:: Journal Article

Journal Name:: International Journal of Radiation Oncology, Biology and Physics

Additional Journal Information:: Journal Volume: 86; Journal Issue: 2; Other Information: Copyright (c) 2013 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; CARBON IONS; HEALTH HAZARDS; IRRADIATION; MELANOMAS; METASTASES; PATIENTS; RADIATION DOSES; RADIOTHERAPY

Citation Formats


                    Toyama, Shingo, Department of Heavy Particle Therapy and Radiation Oncology, Faculty of Medicine, Saga University, Saga, Tsuji, Hiroshi, Mizoguchi, Nobutaka, Nomiya, Takuma, Kamada, Tadashi, Tokumaru, Sunao, Mizota, Atsushi, Ohnishi, Yoshitaka, and Tsujii, Hirohiko. Long-term Results of Carbon Ion Radiation Therapy for Locally Advanced or Unfavorably Located Choroidal Melanoma: Usefulness of CT-based 2-Port Orthogonal Therapy for Reducing the Incidence of Neovascular Glaucoma.  United States: N. p., 2013. 
        Web.  doi:10.1016/J.IJROBP.2012.12.022.

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                    Toyama, Shingo, Department of Heavy Particle Therapy and Radiation Oncology, Faculty of Medicine, Saga University, Saga, Tsuji, Hiroshi, Mizoguchi, Nobutaka, Nomiya, Takuma, Kamada, Tadashi, Tokumaru, Sunao, Mizota, Atsushi, Ohnishi, Yoshitaka, & Tsujii, Hirohiko. Long-term Results of Carbon Ion Radiation Therapy for Locally Advanced or Unfavorably Located Choroidal Melanoma: Usefulness of CT-based 2-Port Orthogonal Therapy for Reducing the Incidence of Neovascular Glaucoma.  United States.  https://doi.org/10.1016/J.IJROBP.2012.12.022

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                    Toyama, Shingo, Department of Heavy Particle Therapy and Radiation Oncology, Faculty of Medicine, Saga University, Saga, Tsuji, Hiroshi, Mizoguchi, Nobutaka, Nomiya, Takuma, Kamada, Tadashi, Tokumaru, Sunao, Mizota, Atsushi, Ohnishi, Yoshitaka, and Tsujii, Hirohiko. 2013.  
        "Long-term Results of Carbon Ion Radiation Therapy for Locally Advanced or Unfavorably Located Choroidal Melanoma: Usefulness of CT-based 2-Port Orthogonal Therapy for Reducing the Incidence of Neovascular Glaucoma".  United States.  https://doi.org/10.1016/J.IJROBP.2012.12.022.

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@article{osti_22224471,

  title        = {Long-term Results of Carbon Ion Radiation Therapy for Locally Advanced or Unfavorably Located Choroidal Melanoma: Usefulness of CT-based 2-Port Orthogonal Therapy for Reducing the Incidence of Neovascular Glaucoma},

  author       = {Toyama, Shingo and Department of Heavy Particle Therapy and Radiation Oncology, Faculty of Medicine, Saga University, Saga and Tsuji, Hiroshi and Mizoguchi, Nobutaka and Nomiya, Takuma and Kamada, Tadashi and Tokumaru, Sunao and Mizota, Atsushi and Ohnishi, Yoshitaka and Tsujii, Hirohiko},

  abstractNote = {Purpose: To determine the long-term results of carbon ion radiation therapy (C-ion RT) in patients with choroidal melanoma, and to assess the usefulness of CT-based 2-port irradiation in reducing the risk of neovascular glaucoma (NVG). Methods and Materials: Between January 2001 and February 2012, a total of 116 patients with locally advanced or unfavorably located choroidal melanoma received CT-based C-ion RT. Of these patients, 114 were followed up for more than 6 months and their data analyzed. The numbers of T3 and T2 patients (International Union Against Cancer [UICC], 5th edition) were 106 and 8, respectively. The total dose of C-ion RT varied from 60 to 85 GyE, with each dose given in 5 fractions. Since October 2005, 2-port therapy (51 patients) has been used in an attempt to reduce the risk of NVG. A dose-volume histogram analysis was also performed in 106 patients. Results: The median follow-up was 4.6 years (range, 0.5-10.6 years). The 5-year overall survival, cause-specific survival, local control, distant metastasis-free survival, and eye retention rates were 80.4% (95% confidence interval 89.0%-71.8%), 82.2% (90.6%-73.8%), 92.8% (98.5%-87.1%), 72.1% (81.9%-62.3%), and 92.8% (98.1%-87.5%), respectively. The overall 5-year NVG incidence rate was 35.9% (25.9%-45.9%) and that of 1-port group and 2-port group were 41.6% (29.3%-54.0%) and 13.9% (3.2%-24.6%) with statistically significant difference (P<.001). The dose-volume histogram analysis showed that the average irradiated volume of the iris-ciliary body was significantly lower in the non-NVG group than in the NVG group at all dose levels, and significantly lower in the 2-port group than in the 1-port group at high dose levels. Conclusions: The long-term results of C-ion RT for choroidal melanoma are satisfactory. CT-based 2-port C-ion RT can be used to reduce the high-dose irradiated volume of the iris-ciliary body and the resulting risk of NVG.},

  doi          = {10.1016/J.IJROBP.2012.12.022},

  url          = {https://www.osti.gov/biblio/22224471},
  journal      = {International Journal of Radiation Oncology, Biology and Physics},

  issn         = {0360-3016},

  number       = 2,

  volume       = 86,

  place        = {United States},

  year         = {Sat Jun 01 00:00:00 EDT 2013},

  month        = {Sat Jun 01 00:00:00 EDT 2013}

}

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