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Title: The Impact of Preradiation Residual Disease Volume on Time to Locoregional Failure in Cutaneous Merkel Cell Carcinoma—A TROG Substudy

Abstract

Purpose: This study evaluated the impact of margin status and gross residual disease in patients treated with chemoradiation therapy for high-risk stage I and II Merkel cell cancer (MCC). Methods and Materials: Data were pooled from 3 prospective trials in which patients were treated with 50 Gy in 25 fractions to the primary lesion and draining lymph nodes and 2 schedules of carboplatin based chemotherapy. Time to locoregional failure was analyzed according to the burden of disease at the time of radiation therapy, comparing patients with negative margins, involved margins, or macroscopic disease. Results: Analysis was performed on 88 patients, of whom 9 had microscopically positive resection margins and 26 had macroscopic residual disease. The majority of gross disease was confined to nodal regions. The 5-year time to locoregional failure, time to distant failure, time to progression, and disease-specific survival rates for the whole group were 73%, 69%, 62%, and 66% respectively. The hazard ratio for macroscopic disease at the primary site or the nodes was 1.25 (95% confidence interval 0.57-2.77), P=.58. Conclusions: No statistically significant differences in time to locoregional failure were identified between patients with negative margins and those with microscopic or gross residual disease. These results must,more » however, be interpreted with caution because of the limited sample size.« less

Authors:
 [1];  [2];  [3]; ; ;  [4];  [5];  [1]
  1. Division of Cancer Services, Princess Alexandra Hospital, University of Queensland, Brisbane (Australia)
  2. Department of Radiation Oncology, Sydney Cancer Centre, University of Sydney, Sydney (Australia)
  3. Calvary Mater Newcastle Hospital, Newcastle (Australia)
  4. Cancer Care Services, Royal Brisbane and Women's Hospital, Brisbane (Australia)
  5. Department of Medical Oncology, Peter MacCallum Cancer Centre, University of Melbourne, Melbourne (Australia)
Publication Date:
OSTI Identifier:
22224448
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 86; Journal Issue: 1; Other Information: Copyright (c) 2013 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CHEMOTHERAPY; FAILURES; HEALTH HAZARDS; LYMPH NODES; NEOPLASMS; PATIENTS; RADIOTHERAPY

Citation Formats

Finnigan, Renee, Hruby, George, Wratten, Chris, Keller, Jacqui, Tripcony, Lee, Dickie, Graeme, Rischin, Danny, and Poulsen, Michael. The Impact of Preradiation Residual Disease Volume on Time to Locoregional Failure in Cutaneous Merkel Cell Carcinoma—A TROG Substudy. United States: N. p., 2013. Web. doi:10.1016/J.IJROBP.2012.11.026.
Finnigan, Renee, Hruby, George, Wratten, Chris, Keller, Jacqui, Tripcony, Lee, Dickie, Graeme, Rischin, Danny, & Poulsen, Michael. The Impact of Preradiation Residual Disease Volume on Time to Locoregional Failure in Cutaneous Merkel Cell Carcinoma—A TROG Substudy. United States. https://doi.org/10.1016/J.IJROBP.2012.11.026
Finnigan, Renee, Hruby, George, Wratten, Chris, Keller, Jacqui, Tripcony, Lee, Dickie, Graeme, Rischin, Danny, and Poulsen, Michael. 2013. "The Impact of Preradiation Residual Disease Volume on Time to Locoregional Failure in Cutaneous Merkel Cell Carcinoma—A TROG Substudy". United States. https://doi.org/10.1016/J.IJROBP.2012.11.026.
@article{osti_22224448,
title = {The Impact of Preradiation Residual Disease Volume on Time to Locoregional Failure in Cutaneous Merkel Cell Carcinoma—A TROG Substudy},
author = {Finnigan, Renee and Hruby, George and Wratten, Chris and Keller, Jacqui and Tripcony, Lee and Dickie, Graeme and Rischin, Danny and Poulsen, Michael},
abstractNote = {Purpose: This study evaluated the impact of margin status and gross residual disease in patients treated with chemoradiation therapy for high-risk stage I and II Merkel cell cancer (MCC). Methods and Materials: Data were pooled from 3 prospective trials in which patients were treated with 50 Gy in 25 fractions to the primary lesion and draining lymph nodes and 2 schedules of carboplatin based chemotherapy. Time to locoregional failure was analyzed according to the burden of disease at the time of radiation therapy, comparing patients with negative margins, involved margins, or macroscopic disease. Results: Analysis was performed on 88 patients, of whom 9 had microscopically positive resection margins and 26 had macroscopic residual disease. The majority of gross disease was confined to nodal regions. The 5-year time to locoregional failure, time to distant failure, time to progression, and disease-specific survival rates for the whole group were 73%, 69%, 62%, and 66% respectively. The hazard ratio for macroscopic disease at the primary site or the nodes was 1.25 (95% confidence interval 0.57-2.77), P=.58. Conclusions: No statistically significant differences in time to locoregional failure were identified between patients with negative margins and those with microscopic or gross residual disease. These results must, however, be interpreted with caution because of the limited sample size.},
doi = {10.1016/J.IJROBP.2012.11.026},
url = {https://www.osti.gov/biblio/22224448}, journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 1,
volume = 86,
place = {United States},
year = {Wed May 01 00:00:00 EDT 2013},
month = {Wed May 01 00:00:00 EDT 2013}
}