Longitudinal Investigation of Adaptive Functioning Following Conformal Irradiation for Pediatric Craniopharyngioma and Low-Grade Glioma

Netson, Kelli L.; Conklin, Heather M.; Wu, Shengjie; Xiong, Xiaoping

doi:10.1016/J.IJROBP.2012.10.031

Title: Longitudinal Investigation of Adaptive Functioning Following Conformal Irradiation for Pediatric Craniopharyngioma and Low-Grade Glioma

Full Record
Other Related Research

Abstract

Purpose: Children treated for brain tumors with conformal radiation therapy experience preserved cognitive outcomes. Early evidence suggests that adaptive functions or independent-living skills may be spared. This longitudinal investigation prospectively examined intellectual and adaptive functioning during the first 5 years following irradiation for childhood craniopharyngioma and low-grade glioma (LGG). The effect of visual impairment on adaptive outcomes was investigated. Methods and Materials: Children with craniopharyngioma (n=62) and LGG (n=77) were treated using conformal or intensity modulated radiation therapy. The median age was 8.05 years (3.21-17.64 years) and 8.09 years (2.20-19.27 years), respectively. Serial cognitive evaluations including measures of intelligence quotient (IQ) and the Vineland Adaptive Behavior Scales (VABS) were conducted at preirradiation baseline, 6 months after treatment, and annually through 5 years. Five hundred eighty-eight evaluations were completed during the follow-up period. Results: Baseline assessment revealed no deficits in IQ and VABS indices for children with craniopharyngioma, with significant (P<.05) longitudinal decline in VABS Communication and Socialization indices. Clinical factors associated with more rapid decline included females and preirradiation chemotherapy (interferon). The only change in VABS Daily Living Skills correlated with IQ change (r=0.34; P=.01) in children with craniopharyngioma. Children with LGG performed below population norms (P<.05) at baseline onmore »« less

Authors:

Netson, Kelli L. ^[1]; Conklin, Heather M. ^[2]; Wu, Shengjie; Xiong, Xiaoping ^[3]

Department of Psychiatry and Behavioral Sciences, Kansas University School of Medicine—Wichita, Kansas (United States)
Department of Psychology, St Jude Children's Research Hospital, Memphis, Tennessee (United States)
Department of Biostatistics, St Jude Children's Research Hospital, Memphis, Tennessee (United States)

Publication Date:: Mon Apr 01 00:00:00 EDT 2013

OSTI Identifier:: 22224421

Resource Type:: Journal Article

Journal Name:: International Journal of Radiation Oncology, Biology and Physics

Additional Journal Information:: Journal Volume: 85; Journal Issue: 5; Other Information: Copyright (c) 2013 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; BRAIN; CHEMOTHERAPY; CHILDREN; EVALUATION; GLIOMAS; INTERFERON; IRRADIATION; PEDIATRICS; RADIOTHERAPY

Citation Formats


                    Netson, Kelli L., Conklin, Heather M., Wu, Shengjie, Xiong, Xiaoping, and Merchant, Thomas E., E-mail: thomas.merchant@stjude.org. Longitudinal Investigation of Adaptive Functioning Following Conformal Irradiation for Pediatric Craniopharyngioma and Low-Grade Glioma.  United States: N. p., 2013. 
        Web.  doi:10.1016/J.IJROBP.2012.10.031.

Copy to clipboard


                    Netson, Kelli L., Conklin, Heather M., Wu, Shengjie, Xiong, Xiaoping, & Merchant, Thomas E., E-mail: thomas.merchant@stjude.org. Longitudinal Investigation of Adaptive Functioning Following Conformal Irradiation for Pediatric Craniopharyngioma and Low-Grade Glioma.  United States.  https://doi.org/10.1016/J.IJROBP.2012.10.031

Copy to clipboard


                    Netson, Kelli L., Conklin, Heather M., Wu, Shengjie, Xiong, Xiaoping, and Merchant, Thomas E., E-mail: thomas.merchant@stjude.org. 2013.  
        "Longitudinal Investigation of Adaptive Functioning Following Conformal Irradiation for Pediatric Craniopharyngioma and Low-Grade Glioma".  United States.  https://doi.org/10.1016/J.IJROBP.2012.10.031.

Copy to clipboard


                    
@article{osti_22224421,

  title        = {Longitudinal Investigation of Adaptive Functioning Following Conformal Irradiation for Pediatric Craniopharyngioma and Low-Grade Glioma},

  author       = {Netson, Kelli L. and Conklin, Heather M. and Wu, Shengjie and Xiong, Xiaoping and Merchant, Thomas E., E-mail: thomas.merchant@stjude.org},

  abstractNote = {Purpose: Children treated for brain tumors with conformal radiation therapy experience preserved cognitive outcomes. Early evidence suggests that adaptive functions or independent-living skills may be spared. This longitudinal investigation prospectively examined intellectual and adaptive functioning during the first 5 years following irradiation for childhood craniopharyngioma and low-grade glioma (LGG). The effect of visual impairment on adaptive outcomes was investigated. Methods and Materials: Children with craniopharyngioma (n=62) and LGG (n=77) were treated using conformal or intensity modulated radiation therapy. The median age was 8.05 years (3.21-17.64 years) and 8.09 years (2.20-19.27 years), respectively. Serial cognitive evaluations including measures of intelligence quotient (IQ) and the Vineland Adaptive Behavior Scales (VABS) were conducted at preirradiation baseline, 6 months after treatment, and annually through 5 years. Five hundred eighty-eight evaluations were completed during the follow-up period. Results: Baseline assessment revealed no deficits in IQ and VABS indices for children with craniopharyngioma, with significant (P<.05) longitudinal decline in VABS Communication and Socialization indices. Clinical factors associated with more rapid decline included females and preirradiation chemotherapy (interferon). The only change in VABS Daily Living Skills correlated with IQ change (r=0.34; P=.01) in children with craniopharyngioma. Children with LGG performed below population norms (P<.05) at baseline on VABS Communication, Daily Living Indices, and the Adaptive Behavior Composite, with significant (P<.05) longitudinal decline limited to VABS Communication. Older age at irradiation was a protective factor against longitudinal decline. Severe visual impairment did not independently correlate with poorer adaptive outcomes for either tumor group. Conclusions: There was relative sparing of postirradiation functional outcomes over time in this sample. Baseline differences in functional abilities before the initiation of irradiation suggested that other factors influence functional outcomes above and beyond the effects of irradiation.},

  doi          = {10.1016/J.IJROBP.2012.10.031},

  url          = {https://www.osti.gov/biblio/22224421},
  journal      = {International Journal of Radiation Oncology, Biology and Physics},

  issn         = {0360-3016},

  number       = 5,

  volume       = 85,

  place        = {United States},

  year         = {Mon Apr 01 00:00:00 EDT 2013},

  month        = {Mon Apr 01 00:00:00 EDT 2013}

}

Copy to clipboard

Journal Article:

https://doi.org/10.1016/J.IJROBP.2012.10.031

Other availability

Find in Google Scholar

Search WorldCat to find libraries that may hold this journal

Save / Share:

Export Metadata

Save to My Library

Similar records in OSTI.GOV collections:

A 5-Year Investigation of Children's Adaptive Functioning Following Conformal Radiation Therapy for Localized Ependymoma

Journal Article Netson, Kelli; Conklin, Heather; Shengjie, Wu; ... - International Journal of Radiation Oncology, Biology and Physics

Purpose: Conformal and intensity modulated radiation therapies have the potential to preserve cognitive outcomes in children with ependymoma; however, functional behavior remains uninvestigated. This longitudinal investigation prospectively examined intelligence quotient (IQ) and adaptive functioning during the first 5 years after irradiation in children diagnosed with ependymoma. Methods and Materials: The study cohort consisted of 123 children with intracranial ependymoma. Mean age at irradiation was 4.60 years (95% confidence interval [CI], 3.85-5.35). Serial neurocognitive evaluations, including an age-appropriate IQ measure and the Vineland Adaptive Behavior Scales (VABS), were completed before irradiation, 6 months after treatment, and annually for 5 years. Amore »« less
https://doi.org/10.1016/J.IJROBP.2011.10.043
Prospective study of cognitive function in children receiving whole-brain radiotherapy and chemotherapy: 2-year results

Journal Article Packer, R; Sutton, L; Atkins, T; ... - Journal of Neurosurgery; (USA)

As survival rates have risen for children with malignant primary brain tumors, so has the concern that many survivors have significant permanent cognitive deficits. Cranial irradiation (CRT) has been implicated as the major cause for cognitive dysfunction. To clarify the etiology, incidence, and severity of intellectual compromise in children with brain tumors after CRT, a prospective study was undertaken comparing the neuropsychological outcome in 18 consecutive children with malignant brain tumors treated with CRT to outcome in 14 children harboring brain tumors in similar sites in the nervous system who had not received CRT. Children with cortical or subcortical brainmore »« less
https://doi.org/10.3171/jns.1989.70.5.0707
Evidence for a discrete behavioral phenotype in the oculocerebrorenal syndrome of Lowe

Journal Article Kenworthy, L; Charnas, L - American Journal of Medical Genetics

The oculocerebrorenal syndrome of Lowe (OCRL) is an X-linked disorder characterized by congenital cataracts, cognitive impairment, and renal tubular dysfunction. Although there is a wide range of intellectual function in affected individuals, it is often compromised by a high prevalence of maladaptive behaviors, including tantrums, stubbornness, and stereotypy. Whether these behaviors simply reflect the multiple disabilities found in some developmentally impaired individuals with or without OCRL, or a specific genetically-determined behavioral phenotype of OCRL, is unknown. Controls were matched for sex, age, visual impairment, and adaptive functioning and compared with OCRL patients on three standardized measures of adaptive/maladaptive behaviors. Forty-threemore »« less
https://doi.org/10.1002/ajmg.1320590304
Early Cognitive Outcomes Following Proton Radiation in Pediatric Patients With Brain and Central Nervous System Tumors

Journal Article Sethi, Roshan; Kuhlthau, Karen; MacDonald, Shannon; ... - International Journal of Radiation Oncology, Biology and Physics

Purpose: To report, from a longitudinal study, cognitive outcome in pediatric patients treated with proton radiation therapy (PRT) for central nervous system (CNS) tumors. Methods and Materials: Sixty patients receiving PRT for medulloblastoma (38.3%), gliomas (18.3%), craniopharyngioma (15.0%), ependymoma (11.7%), and other CNS tumors (16.7%) were administered age-appropriate measures of cognitive abilities at or near PRT initiation (baseline) and afterward (follow-up). Patients were aged ≥6 years at baseline to ensure consistency in neurocognitive measures. Results: Mean age was 12.3 years at baseline; mean follow-up interval was 2.5 years. Treatment included prior surgical resection (76.7%) and chemotherapy (61.7%). Proton radiation therapy included craniospinal irradiationmore »« less
https://doi.org/10.1016/J.IJROBP.2015.06.012
Learning and Memory Following Conformal Radiation Therapy for Pediatric Craniopharyngioma and Low-Grade Glioma

Journal Article Di Pinto, Marcos; Conklin, Heather; Li, Chenghong - International Journal of Radiation Oncology, Biology and Physics

Purpose: The primary objective of this study was to examine whether children with low-grade glioma (LGG) or craniopharyngioma had impaired learning and memory after conformal radiation therapy (CRT). A secondary objective was to determine whether children who received chemotherapy before CRT, a treatment often used to delay radiation therapy in younger children with LGG, received any protective benefit with respect to learning. Methods and Materials: Learning and memory in 57 children with LGG and 44 children with craniopharyngioma were assessed with the California Verbal Learning Test-Children's Version and the Visual-Auditory Learning tests. Learning measures were administered before CRT, 6 monthsmore »« less
https://doi.org/10.1016/J.IJROBP.2012.03.066

Similar Records