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Title: Chromosome aberrations and cellular premature senescence as radiation-induced sub-lethal effects: Implications for laser-driven charged-particle radiotherapy

The use of charged particles significantly reduces the dose absorbed by normal cells due to the inverse dose-depth deposition profile. This is the physical pillar justifying hadrontherapy as the eligible treatment for deepseated tumours. However, a non-negligible amount of radiation is nevertheless absorbed in correspondence with the plateau region of the Bragg curve, which may result in the induction of sub-lethal effects. Very little experimental data exist on the induction of such effects. Moreover, reliable follow-up data on such adverse effects in hadrontherapy patients are limited since this type of treatment has been adopted relatively recently. A fortiori, the dependence of sub-lethal effects on unprecedented factors, such as the exceedingly high dose rates and/or the pulsed nature of beams originated by laser interaction with target materials, is unknown. This warrants investigation prior to a therapeutic use of such beams.
Authors:
; ;  [1]
  1. Department of Physical Sciences, University of Naples Federico II and INFN-Naples Section, Via Cintia, 80126 Naples (Italy)
Publication Date:
OSTI Identifier:
22218284
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 1546; Journal Issue: 1; Conference: 2. ELIMED workshop and panel, Catania (Italy), 18-19 Oct 2012; Other Information: (c) 2013 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ABSORBED RADIATION DOSES; BIOLOGICAL RADIATION EFFECTS; BRAGG CURVE; CHARGED PARTICLES; CHROMOSOMAL ABERRATIONS; DOSE RATES; DOSIMETRY; IRRADIATION; LASERS; PARTICLE BEAMS; PATIENTS; PULSED IRRADIATION; RADIOTHERAPY; THERAPEUTIC USES