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Title: First results on cell irradiation with laser-driven protons on the TARANIS system

The ultra short duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen’s University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 10{sup 9} Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live, cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4±0.2 at 10% survival is estimated from a comparison with a 225 kVp X-ray source.
Authors:
; ; ; ; ; ; ; ;  [1] ;  [2] ; ;  [3] ; ; ;  [4] ; ; ;  [5]
  1. School of Mathematics and Physics, Queen's University Belfast, Belfast BT7 1NN (United Kingdom)
  2. School of Mathematics and Physics, Queen's University Belfast, Belfast BT7 1NN, UK and Institute of Physics of the ASCR, ELI-Beamlines Project, Prague (Czech Republic)
  3. CCRCB, Queen's University Belfast, Belfast BT7 1NN (United Kingdom)
  4. Dept. of Medical Physics, University Hospital, Birmingham, B15 2TH (United Kingdom)
  5. Ion Beam Centre, University of Surrey, Guildford GU2 7XH (United Kingdom)
Publication Date:
OSTI Identifier:
22218283
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 1546; Journal Issue: 1; Conference: 2. ELIMED workshop and panel, Catania (Italy), 18-19 Oct 2012; Other Information: (c) 2013 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BIOLOGICAL RADIATION EFFECTS; COMPARATIVE EVALUATIONS; DOSE RATES; EQUIVALENT RADIATION DOSES; IRRADIATION; MEV RANGE; PROTON BEAMS; PROTONS; RADIOTHERAPY; RBE; X-RAY SOURCES