Single shot cell irradiations with laser-driven protons

Journal Article · Fri Jul 26 00:00:00 EDT 2013 · AIP Conference Proceedings

DOI:https://doi.org/10.1063/1.4816611· OSTI ID:22218282

Humble, N.; Schmid, T. E.; Zlobinskaya, O.; Wilkens, J. J. ^[1]; Allinger, K.; Hilz, P.; Ma, W.; Reinhardt, S. ^[2]; Bin, J.; Kiefer, D.; Schreiber, J. ^[3]; Drexler, G. A.; Friedl, A. ^[4]

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1. Department of Radiation Oncology, Klinikum rechts der Isar, Technische Universität München (Germany)
2. Physics Department, Ludwig-Maximilians-Universität München (Germany)
3. Max Planck Institute of Quantum Optics, Garching (Germany)
4. Department of Radiation Oncology, Ludwig-Maximilians-Universität München (Germany)

Ion beams are relevant for radiobiological studies in basic research and for application in tumor therapy. Here we present a method to generate nanosecond proton bunches with single shot doses of up to 7 Gray by a tabletop high-power laser. Although in their infancy, laser-ion accelerators allow studying fast radiobiological processes at small-scale laboratories as exemplarily demonstrated by measurements of the relative biological effectiveness of protons in human tumor cells.

• OSTI ID: 22218282
• Journal Information: AIP Conference Proceedings, Vol. 1546, Issue 1; Conference: 2. ELIMED workshop and panel, Catania (Italy), 18-19 Oct 2012; Other Information: (c) 2013 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA); ISSN 0094-243X
• Country of Publication: United States
• Language: English

Related Subjects

43 PARTICLE ACCELERATORS
62 RADIOLOGY AND NUCLEAR MEDICINE
ACCELERATORS
BEAM BUNCHING
BEAM PRODUCTION
BIOLOGICAL RADIATION EFFECTS
HUMAN POPULATIONS
ION BEAMS
LASER-PRODUCED PLASMA
LASERS
NEOPLASMS
PROTON BEAMS
PROTONS
RADIATION DOSE UNITS
RADIOTHERAPY
RBE
TUMOR CELLS