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Title: Radiobiology challenges for ELIMED

Laser driven accelerators have been proposed for possible clinical applications facilities with the clear aim to reduce the facilities overall cost and complexity of at least one order of magnitude compared to currently employed accelerators. While significant efforts is on-going in the physics community to achieve the required ion beam parameters for medical applications and design suitable radiotherapy facilities, radiobiological investigations of the effects of such beams is also mandatory in order to validate their future therapeutic use. The main aim of these investigations has been initially to establish a procedure for cell handling, irradiation and dosimetry compatible with the mixed beam, continuous energy spread and ultra-high dose rate of the pulsed particle beams produced by high power lasers. Moreover, ions are emitted in bursts of picosecond duration at the source and their therapeutic use may result in dose rates exceeding 10{sup 9} Gy/sec and the biological effects at these ultra-high dose rates are virtually unknown.
Authors:
 [1]
  1. CCRCB, Biology, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL and NPL, Hampton Road, Teddington, TW11 0LW (United Kingdom)
Publication Date:
OSTI Identifier:
22218273
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 1546; Journal Issue: 1; Conference: 2. ELIMED workshop and panel, Catania (Italy), 18-19 Oct 2012; Other Information: (c) 2013 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
61 RADIATION PROTECTION AND DOSIMETRY; 71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS; BEAM PRODUCTION; BIOLOGICAL RADIATION EFFECTS; COMPARATIVE EVALUATIONS; DESIGN; DOSE RATES; DOSIMETRY; DRUGS; ION BEAMS; LASER RADIATION; PARTICLE BEAMS; PULSED IRRADIATION; RADIOBIOLOGY; RADIOTHERAPY; THERAPEUTIC USES