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Title: Photoactivatable carbon nanodots for cancer therapy

In this study, we describe a photocatalytic system based on spherical fluorescent carbon-core nanoparticles (nanodots) that can be activated with ultraviolet radiation. The carbon nanodots with a poly(propionylethylenimine-co-ethylenimine) coating were investigated in human prostate adenocarcinoma (Du145 and PC3) cell cultures in vitro. The cells become more sensitive to ultraviolet radiation when preincubated with the nanodots. The inverse slope of the cell survival curves is about 20–30% lower for the carbon nanodots and radiation compared to that for the radiation alone. Such photoactivatable carbon nanodots can be suggested for use in photocatalytic and photodynamic applications.
Authors:
;  [1] ; ;  [2]
  1. Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Montebello 0310 Oslo (Norway)
  2. Department of Chemistry and Laboratory for Emerging Materials and Technology, Clemson University, Clemson, South Carolina 29634-0973 (United States)
Publication Date:
OSTI Identifier:
22218218
Resource Type:
Journal Article
Resource Relation:
Journal Name: Applied Physics Letters; Journal Volume: 103; Journal Issue: 6; Other Information: (c) 2013 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
77 NANOSCIENCE AND NANOTECHNOLOGY; 60 APPLIED LIFE SCIENCES; CARBON; CARCINOMAS; CELL CULTURES; COMPARATIVE EVALUATIONS; FILMS; FLUORESCENCE; HUMAN POPULATIONS; PHOTOCATALYSIS; POLYMERS; PROSTATE; QUANTUM DOTS; SURVIVAL CURVES; THERAPY; ULTRAVIOLET RADIATION