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Title: Phase contrast tomography of the mouse cochlea at microfocus x-ray sources

We present phase contrast x-ray tomography of functional soft tissue within the bony cochlear capsule of mice, carried out at laboratory microfocus sources with well-matched source, detector, geometry, and reconstruction algorithms at spatial resolutions down to 2 μm. Contrast, data quality and resolution enable the visualization of thin membranes and nerve fibers as well as automated segmentation of surrounding bone. By complementing synchrotron radiation imaging techniques, a broad range of biomedical applications becomes possible as demonstrated for optogenetic cochlear implant research.
Authors:
;  [1] ;  [2] ;  [3] ;  [2] ;  [3] ;  [3] ;  [1] ;  [3]
  1. Institute for X-Ray Physics, University of Göttingen, Göttingen (Germany)
  2. InnerEarLab, Department of Otolaryngology, University Medical Center Göttingen, Göttingen (Germany)
  3. (Germany)
Publication Date:
OSTI Identifier:
22218138
Resource Type:
Journal Article
Resource Relation:
Journal Name: Applied Physics Letters; Journal Volume: 103; Journal Issue: 8; Other Information: (c) 2013 © 2013 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 Unported License.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ALGORITHMS; ANIMAL TISSUES; AUDITORY ORGANS; CAPSULES; COMPUTERIZED TOMOGRAPHY; FIBERS; GEOMETRY; IMAGE PROCESSING; IMAGES; IMPLANTS; MEMBRANES; MICE; SKELETON; SPATIAL RESOLUTION; SYNCHROTRON RADIATION; X RADIATION; X-RAY SOURCES