Phase contrast tomography of the mouse cochlea at microfocus x-ray sources
- Institute for X-Ray Physics, University of Göttingen, Göttingen (Germany)
- InnerEarLab, Department of Otolaryngology, University Medical Center Göttingen, Göttingen (Germany)
We present phase contrast x-ray tomography of functional soft tissue within the bony cochlear capsule of mice, carried out at laboratory microfocus sources with well-matched source, detector, geometry, and reconstruction algorithms at spatial resolutions down to 2 μm. Contrast, data quality and resolution enable the visualization of thin membranes and nerve fibers as well as automated segmentation of surrounding bone. By complementing synchrotron radiation imaging techniques, a broad range of biomedical applications becomes possible as demonstrated for optogenetic cochlear implant research.
- OSTI ID:
- 22218138
- Journal Information:
- Applied Physics Letters, Vol. 103, Issue 8; Other Information: (c) 2013 © 2013 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 Unported License.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0003-6951
- Country of Publication:
- United States
- Language:
- English
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