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Title: Feasibility study of endoscopic x-ray luminescence computed tomography: Simulation demonstration and phantom application

Even though endoscopic fluorescence diffuse optical tomography (eFDOT) exhibits significant potential, currently its application is limited due to the existence of strong autofluorescence and the imaging inaccuracy caused by a very short source-detector distance. Motivated by the emerging X-ray luminescence computed tomography (XLCT) technology, we presented an endoscopic XLCT (eXLCT) methodology. In the methodology, the aperture angle of the objective was incorporated into the forward model, providing a more accurate description of light propagation. Numerical simulation with a heterogeneous geometry and an imaging experiment with a physical phantom were illustrated to demonstrate the feasibility of the presented eXLCT methodology.
Authors:
; ; ; ;  [1] ;  [2] ;  [1] ;  [3]
  1. School of Life Science and Technology, Xidian University, Xi'an 710071 (China)
  2. Department of Biomedical and Aerospace Engineering, Universidad Carlos III de Madrid, 28911 Leganes, Madrid (Spain)
  3. (China)
Publication Date:
OSTI Identifier:
22218106
Resource Type:
Journal Article
Resource Relation:
Journal Name: Journal of Applied Physics; Journal Volume: 114; Journal Issue: 8; Other Information: (c) 2013 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 36 MATERIALS SCIENCE; APERTURES; COMPUTERIZED SIMULATION; COMPUTERIZED TOMOGRAPHY; FEASIBILITY STUDIES; FLUORESCENCE; GEOMETRY; IMAGE PROCESSING; LIGHT TRANSMISSION; NUMERICAL ANALYSIS; PHANTOMS; X RADIATION