Feasibility study of endoscopic x-ray luminescence computed tomography: Simulation demonstration and phantom application
- School of Life Science and Technology, Xidian University, Xi'an 710071 (China)
- Department of Biomedical and Aerospace Engineering, Universidad Carlos III de Madrid, 28911 Leganes, Madrid (Spain)
Even though endoscopic fluorescence diffuse optical tomography (eFDOT) exhibits significant potential, currently its application is limited due to the existence of strong autofluorescence and the imaging inaccuracy caused by a very short source-detector distance. Motivated by the emerging X-ray luminescence computed tomography (XLCT) technology, we presented an endoscopic XLCT (eXLCT) methodology. In the methodology, the aperture angle of the objective was incorporated into the forward model, providing a more accurate description of light propagation. Numerical simulation with a heterogeneous geometry and an imaging experiment with a physical phantom were illustrated to demonstrate the feasibility of the presented eXLCT methodology.
- OSTI ID:
- 22218106
- Journal Information:
- Journal of Applied Physics, Vol. 114, Issue 8; Other Information: (c) 2013 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA); ISSN 0021-8979
- Country of Publication:
- United States
- Language:
- English
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