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Title: A first generation compact microbeam radiation therapy system based on carbon nanotube X-ray technology

We have developed a compact microbeam radiation therapy device using carbon nanotube cathodes to create a linear array of narrow focal line segments on a tungsten anode and a custom collimator assembly to select a slice of the resulting wedge-shaped radiation pattern. Effective focal line width was measured to be 131 μm, resulting in a microbeam width of ∼300 μm. The instantaneous dose rate was projected to be 2 Gy/s at full-power. Peak to valley dose ratio was measured to be >17 when a 1.4 mm microbeam separation was employed. Finally, multiple microbeams were delivered to a mouse with beam paths verified through histology.
Authors:
; ;  [1] ; ;  [1] ;  [2] ; ;  [3] ;  [4] ;  [5] ; ;  [1] ;  [2]
  1. Department of Physics and Astronomy, University of North Carolina, Chapel Hill, North Carolina 27599 (United States)
  2. (United States)
  3. XinRay Systems, Inc., 7020 Kit Creek Road, Suite 210, Research Triangle Park, North Carolina 27709 (United States)
  4. Curriculum in Applied and Materials Sciences, University of North Carolina, Chapel Hill, North Carolina 27599 (United States)
  5. Biomedical Research Imaging Center, University of North Carolina, Chapel Hill, North Carolina 27599 (United States)
Publication Date:
OSTI Identifier:
22217795
Resource Type:
Journal Article
Resource Relation:
Journal Name: Applied Physics Letters; Journal Volume: 103; Journal Issue: 18; Other Information: (c) 2013 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ANODES; CARBON NANOTUBES; CATHODES; COLLIMATORS; DOSIMETRY; EQUIPMENT; LINE WIDTHS; MICE; RADIATION DOSES; RADIOTHERAPY; TUNGSTEN; X RADIATION