Exposure to particulate hexavalent chromium exacerbates allergic asthma pathology
Abstract
Airborne hexavalent chromate, Cr(VI), has been identified by the Environmental Protection Agency as a possible health threat in urban areas, due to the carcinogenic potential of some of its forms. Particulate chromates are produced in many different industrial settings, with high levels of aerosolized forms historically documented. Along with an increased risk of lung cancer, a high incidence of allergic asthma has been reported in workers exposed to certain inhaled particulate Cr(VI) compounds. However, a direct causal association between Cr(VI) and allergic asthma has not been established. We recently showed that inhaled particulate Cr(VI) induces an innate neutrophilic inflammatory response in BALB/c mice. In the current studies we investigated how the inflammation induced by inhaled particulate Cr(VI) might alter the pathology of an allergic asthmatic response. We used a well-established mouse model of allergic asthma. Groups of ovalbumin protein (OVA)-primed mice were challenged either with OVA alone, or with a combination of OVA and particulate zinc chromate, and various parameters associated with asthmatic responses were measured. Co-exposure to particulate Cr(VI) and OVA mediated a mixed form of asthma in which both eosinophils and neutrophils are present in airways, tissue pathology is markedly exacerbated, and airway hyperresponsiveness is significantly increased. Takenmore »
- Authors:
-
- Department of Microbiology, Immunology and Tropical Medicine, The George Washington University, Washington, DC 20037 (United States)
- Department of Pharmacology and Physiology, The George Washington University, Washington, DC 20037 (United States)
- Department of Anatomy and Regenerative Biology, The George Washington University, Washington, DC 20037 (United States)
- Publication Date:
- OSTI Identifier:
- 22215238
- Resource Type:
- Journal Article
- Journal Name:
- Toxicology and Applied Pharmacology
- Additional Journal Information:
- Journal Volume: 259; Journal Issue: 1; Other Information: Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0041-008X
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES; AMINO ACIDS; ASTHMA; CARCINOGENS; CHROMATES; CHROMIUM; EOSIN; EOSINOPHILS; HEMATOXYLIN; IMMUNOGLOBULINS; INFLAMMATION; INHALATION; LUNGS; MICE; NEOPLASMS; NEUTROPHILS; OVA; OVALBUMIN; PATHOLOGY; PERIODIC ACID; PHENOTYPE
Citation Formats
Schneider, Brent C., Department of Pharmacology and Physiology, The George Washington University, Washington, DC 20037, Constant, Stephanie L., Patierno, Steven R., GW Cancer Institute, The George Washington University, Washington, DC 20037, Jurjus, Rosalyn A., and Ceryak, Susan M., E-mail: phmsmc@gwumc.edu. Exposure to particulate hexavalent chromium exacerbates allergic asthma pathology. United States: N. p., 2012.
Web. doi:10.1016/J.TAAP.2011.12.001.
Schneider, Brent C., Department of Pharmacology and Physiology, The George Washington University, Washington, DC 20037, Constant, Stephanie L., Patierno, Steven R., GW Cancer Institute, The George Washington University, Washington, DC 20037, Jurjus, Rosalyn A., & Ceryak, Susan M., E-mail: phmsmc@gwumc.edu. Exposure to particulate hexavalent chromium exacerbates allergic asthma pathology. United States. https://doi.org/10.1016/J.TAAP.2011.12.001
Schneider, Brent C., Department of Pharmacology and Physiology, The George Washington University, Washington, DC 20037, Constant, Stephanie L., Patierno, Steven R., GW Cancer Institute, The George Washington University, Washington, DC 20037, Jurjus, Rosalyn A., and Ceryak, Susan M., E-mail: phmsmc@gwumc.edu. 2012.
"Exposure to particulate hexavalent chromium exacerbates allergic asthma pathology". United States. https://doi.org/10.1016/J.TAAP.2011.12.001.
@article{osti_22215238,
title = {Exposure to particulate hexavalent chromium exacerbates allergic asthma pathology},
author = {Schneider, Brent C. and Department of Pharmacology and Physiology, The George Washington University, Washington, DC 20037 and Constant, Stephanie L. and Patierno, Steven R. and GW Cancer Institute, The George Washington University, Washington, DC 20037 and Jurjus, Rosalyn A. and Ceryak, Susan M., E-mail: phmsmc@gwumc.edu},
abstractNote = {Airborne hexavalent chromate, Cr(VI), has been identified by the Environmental Protection Agency as a possible health threat in urban areas, due to the carcinogenic potential of some of its forms. Particulate chromates are produced in many different industrial settings, with high levels of aerosolized forms historically documented. Along with an increased risk of lung cancer, a high incidence of allergic asthma has been reported in workers exposed to certain inhaled particulate Cr(VI) compounds. However, a direct causal association between Cr(VI) and allergic asthma has not been established. We recently showed that inhaled particulate Cr(VI) induces an innate neutrophilic inflammatory response in BALB/c mice. In the current studies we investigated how the inflammation induced by inhaled particulate Cr(VI) might alter the pathology of an allergic asthmatic response. We used a well-established mouse model of allergic asthma. Groups of ovalbumin protein (OVA)-primed mice were challenged either with OVA alone, or with a combination of OVA and particulate zinc chromate, and various parameters associated with asthmatic responses were measured. Co-exposure to particulate Cr(VI) and OVA mediated a mixed form of asthma in which both eosinophils and neutrophils are present in airways, tissue pathology is markedly exacerbated, and airway hyperresponsiveness is significantly increased. Taken together these findings suggest that inhalation of particulate forms of Cr(VI) may augment the severity of ongoing allergic asthma, as well as alter its phenotype. Such findings may have implications for asthmatics in settings in which airborne particulate Cr(VI) compounds are present at high levels. -- Highlights: ► Allergic asthma correlated with exposure to certain inhaled particulate chromates. ► Direct causal association between Cr(VI) and allergic asthma not established. ► Cr exacerbated pathology and airway hyperresponsiveness in an OVA-challenged mouse. ► Particulate Cr(VI) may augment severity and alter phenotype of ongoing allergic asthma.},
doi = {10.1016/J.TAAP.2011.12.001},
url = {https://www.osti.gov/biblio/22215238},
journal = {Toxicology and Applied Pharmacology},
issn = {0041-008X},
number = 1,
volume = 259,
place = {United States},
year = {Wed Feb 15 00:00:00 EST 2012},
month = {Wed Feb 15 00:00:00 EST 2012}
}