Chemokines in cancer related inflammation

Journal Article · Thu Mar 10 00:00:00 EST 2011 · Experimental Cell Research

DOI:https://doi.org/10.1016/J.YEXCR.2010.11.013· OSTI ID:22212097

Allavena, Paola; Germano, Giovanni; Marchesi, Federica ^[1]; Mantovani, Alberto ^[1]

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1. Department of Immunology and Inflammation, IRCCS Humanitas Clinical Institute, Via Manzoni 56, 20089, Rozzano, Milan (Italy)

Chemokines are key players of the cancer-related inflammation. Chemokine ligands and receptors are downstream of genetic events that cause neoplastic transformation and are abundantly expressed in chronic inflammatory conditions which predispose to cancer. Components of the chemokine system affect multiple pathways of tumor progression including: leukocyte recruitment, neo-angiogenesis, tumor cell proliferation and survival, invasion and metastasis. Evidence in pre-clinical and clinical settings suggests that the chemokine system represents a valuable target for the development of innovative therapeutic strategies.

• OSTI ID: 22212097
• Journal Information: Experimental Cell Research, Vol. 317, Issue 5; Other Information: Copyright (c) 2010 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0014-4827
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
ANGIOGENESIS
INFLAMMATION
LEUKOCYTES
LIGANDS
MACROPHAGES
METASTASES
NEOPLASMS
RECEPTORS
TUMOR CELLS