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Title: MicroRNA-650 targets ING4 to promote gastric cancer tumorigenicity

Abstract

MicroRNAs (miRNAs) are non-coding RNAs that regulate the expression of target mRNAs. Altered expression of specific miRNAs in human gastric cancer progression has been reported; however, the role of miR-650 in gastric cancer is poorly understood. In this study, we show that miR-650 is involved in lymphatic and distant metastasis in human gastric cancer, and we find that ectopic expression of miR-650 promotes tumorigenesis and proliferation of gastric cancer cells. A luciferase reporter assay demonstrates that Inhibitor of Growth 4 (ING4) is a direct target of miR-650. Collectively, our study demonstrates that over-expression of miR-650 in gastric cancer may promote proliferation and growth of cancer cells, at least partially through directly targeting ING4. These findings help clarify the molecular mechanisms involved in gastric carcinogenesis and indicate that miR-650 modulation may be a bona fide miRNA-based treatment of gastric cancer.

Authors:
 [1];  [2];  [1]; ; ;  [1];  [1]
  1. Department of General Surgery of FenXian Hospital, Affiliated to Southern Medical University, 9588 Nan Fen Road, Shanghai 233400 (China)
  2. Department of General Surgery of HuanShan Hospital, Affiliated to FuDan University, 12 Wu Lu Mu Qi Road, Shanghai 200040 (China)
Publication Date:
OSTI Identifier:
22202500
Resource Type:
Journal Article
Journal Name:
Biochemical and Biophysical Research Communications
Additional Journal Information:
Journal Volume: 395; Journal Issue: 2; Other Information: Copyright (c) 2010 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0006-291X
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; CARCINOGENESIS; CELL PROLIFERATION; HUMAN POPULATIONS; LUCIFERASE; MESSENGER-RNA; METASTASES; NEOPLASMS

Citation Formats

Zhang, XueLi, Zhu, WeiYing, Zhang, JiFa, Department of General Surgery of HuanShan Hospital, Affiliated to FuDan University, 12 Wu Lu Mu Qi Road, Shanghai 200040, Huo, ShouJun, Zhou, LianMing, Gu, Zhen, and Zhang, Min. MicroRNA-650 targets ING4 to promote gastric cancer tumorigenicity. United States: N. p., 2010. Web. doi:10.1016/J.BBRC.2010.04.005.
Zhang, XueLi, Zhu, WeiYing, Zhang, JiFa, Department of General Surgery of HuanShan Hospital, Affiliated to FuDan University, 12 Wu Lu Mu Qi Road, Shanghai 200040, Huo, ShouJun, Zhou, LianMing, Gu, Zhen, & Zhang, Min. MicroRNA-650 targets ING4 to promote gastric cancer tumorigenicity. United States. https://doi.org/10.1016/J.BBRC.2010.04.005
Zhang, XueLi, Zhu, WeiYing, Zhang, JiFa, Department of General Surgery of HuanShan Hospital, Affiliated to FuDan University, 12 Wu Lu Mu Qi Road, Shanghai 200040, Huo, ShouJun, Zhou, LianMing, Gu, Zhen, and Zhang, Min. 2010. "MicroRNA-650 targets ING4 to promote gastric cancer tumorigenicity". United States. https://doi.org/10.1016/J.BBRC.2010.04.005.
@article{osti_22202500,
title = {MicroRNA-650 targets ING4 to promote gastric cancer tumorigenicity},
author = {Zhang, XueLi and Zhu, WeiYing and Zhang, JiFa and Department of General Surgery of HuanShan Hospital, Affiliated to FuDan University, 12 Wu Lu Mu Qi Road, Shanghai 200040 and Huo, ShouJun and Zhou, LianMing and Gu, Zhen and Zhang, Min},
abstractNote = {MicroRNAs (miRNAs) are non-coding RNAs that regulate the expression of target mRNAs. Altered expression of specific miRNAs in human gastric cancer progression has been reported; however, the role of miR-650 in gastric cancer is poorly understood. In this study, we show that miR-650 is involved in lymphatic and distant metastasis in human gastric cancer, and we find that ectopic expression of miR-650 promotes tumorigenesis and proliferation of gastric cancer cells. A luciferase reporter assay demonstrates that Inhibitor of Growth 4 (ING4) is a direct target of miR-650. Collectively, our study demonstrates that over-expression of miR-650 in gastric cancer may promote proliferation and growth of cancer cells, at least partially through directly targeting ING4. These findings help clarify the molecular mechanisms involved in gastric carcinogenesis and indicate that miR-650 modulation may be a bona fide miRNA-based treatment of gastric cancer.},
doi = {10.1016/J.BBRC.2010.04.005},
url = {https://www.osti.gov/biblio/22202500}, journal = {Biochemical and Biophysical Research Communications},
issn = {0006-291X},
number = 2,
volume = 395,
place = {United States},
year = {Fri Apr 30 00:00:00 EDT 2010},
month = {Fri Apr 30 00:00:00 EDT 2010}
}