Unlike PPAR{gamma}, PPAR{alpha} or PPAR{beta}/{delta} activation does not promote human monocyte differentiation toward alternative macrophages

Journal Article · Fri Aug 28 00:00:00 EDT 2009 · Biochemical and Biophysical Research Communications

DOI:https://doi.org/10.1016/J.BBRC.2009.06.047· OSTI ID:22199774

Bouhlel, Mohamed Amine ^[1]; Inserm U545, F-59000 Lille ^[2]; UDSL, F-59000 Lille ^[2]; Brozek, John ^[3]; Derudas, Bruno ^[1]; Inserm U545, F-59000 Lille ^[2]; UDSL, F-59000 Lille ^[2]; Zawadzki, Christophe; Jude, Brigitte ^[4]; Staels, Bart ^[1]; Inserm U545, F-59000 Lille ^[2]; UDSL, F-59000 Lille ^[2]; Chinetti-Gbaguidi, Giulia ^[1]; Inserm U545, F-59000 Lille ^[2]; UDSL, F-59000 Lille ^[2]

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1. Univ Lille Nord de France, F-59000 Lille (France)
2. France
3. Genfit, Loos (France)
4. Inserm ERI-9 and Equipe d'Accueil 2693, IFR114, Universite de Lille, Lille (France)

Macrophages adapt their response to micro-environmental signals. While Th1 cytokines promote pro-inflammatory M1 macrophages, Th2 cytokines promote an 'alternative' anti-inflammatory M2 macrophage phenotype. Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors expressed in macrophages where they control the inflammatory response. It has been shown that PPAR{gamma} promotes the differentiation of monocytes into anti-inflammatory M2 macrophages in humans and mice, while a role for PPAR{beta}/{delta} in this process has been reported only in mice and no data are available for PPAR{alpha}. Here, we show that in contrast to PPAR{gamma}, expression of PPAR{alpha} and PPAR{beta}/{delta} overall does not correlate with the expression of M2 markers in human atherosclerotic lesions, whereas a positive correlation with genes of lipid metabolism exists. Moreover, unlike PPAR{gamma}, PPAR{alpha} or PPAR{beta}/{delta} activation does not influence human monocyte differentiation into M2 macrophages in vitro. Thus, PPAR{alpha} and PPAR{beta}/{delta} do not appear to modulate the alternative differentiation of human macrophages.

• OSTI ID: 22199774
• Journal Information: Biochemical and Biophysical Research Communications, Vol. 386, Issue 3; Other Information: Copyright (c) 2009 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
ARTERIOSCLEROSIS
IN VITRO
INFLAMMATION
LIGANDS
LIPIDS
LYMPHOKINES
MACROPHAGES
METABOLISM
MICE
MONOCYTES
PHENOTYPE
RECEPTORS
SIGNALS
TRANSCRIPTION FACTORS