Transcription factors involved in glucose-stimulated insulin secretion of pancreatic beta cells

Journal Article · Fri Jul 10 00:00:00 EDT 2009 · Biochemical and Biophysical Research Communications

DOI:https://doi.org/10.1016/J.BBRC.2009.04.135· OSTI ID:22199735

Shao, Shiying ^[1]; Fang, Zhong ^[2]; Yu, Xuefeng; Zhang, Muxun ^[1]

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1. Division of Endocrinology, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan (China)
2. Division of Orthopedics, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan (China)

GSIS, the most important function of pancreatic beta cell, is essential for maintaining the glucose homeostasis. Transcription factors are known to control different biological processes such as differentiation, proliferation and apoptosis. In pancreas, some transcription factors are involved in regulating the function of beta cells. In this review, the role of these transcription factors including Pdx-1, FoxO1, SREBP-1c, and MafA in GSIS is highlighted. The related molecular mechanisms are analyzed as well. Furthermore, the association between the role of transcription factors in GSIS and the development of T2DM is discussed.

• OSTI ID: 22199735
• Journal Information: Biochemical and Biophysical Research Communications, Vol. 384, Issue 4; Other Information: Copyright (c) 2009 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
APOPTOSIS
GLUCOSE
HOMEOSTASIS
INSULIN
PANCREAS
REVIEWS
SECRETION
TRANSCRIPTION FACTORS