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Title: Acute changes in pulse pressure in relation to constituents of particulate air pollution in elderly persons

Abstract

An increased pulse pressure (difference between systolic and diastolic blood pressure) suggests aortic stiffening. The objective of this study was to examine the acute effects of both particulate matter (PM) mass and composition on blood pressure, among elderly persons. We carried out a panel study in persons living in elderly homes in Antwerp, Belgium. We recruited 88 non-smoking persons, 70% women with a mean age of 83 years (standard deviation: 5.2). Blood pressure was measured and a blood sample was collected on two time points, which were chosen so that there was an exposure contrast in ambient PM exposure. The elemental content of the collected indoor and outdoor PM{sub 2.5} (particulate matter with an aerodynamic diameter <2.5 {mu}m) mass concentration was measured. Oxygenated polycyclic aromatic hydrocarbons (oxy-PAHs) on outdoor PM{sub 10} (particulate matter with an aerodynamic diameter <10 {mu}m) were measured. Each interquartile range increase of 20.8 {mu}g/m Superscript-Three in 24-h mean outdoor PM{sub 2.5} was associated with an increase in pulse pressure of 4.0 mmHg (95% confidence interval: 1.8-6.2), in persons taking antihypertensive medication (n=57), but not in persons not using antihypertensive medication (n=31) (p for interaction: 0.02). Vanadium, iron and nickel contents of PM{sub 2.5} were significantly associatedmore » with systolic blood pressure and pulse pressure, among persons on antihypertensive medication. Similar results were found for indoor concentrations. Of the oxy-PAHs, chrysene-5,6-dione and benzo[a]pyrene-3,6-dione were significantly associated with increases in systolic blood pressure and pulse pressure. In elderly, pulse pressure was positively associated with acute increases in outdoor and indoor air pollution, among persons taking antihypertensive medication. These results might form a mechanistic pathway linking air pollution as a trigger of cardiovascular events.« less

Authors:
 [1];  [2];  [3];  [4];  [2];  [2]; ; ;  [3];  [4];  [1];  [1]
  1. Occupational and Environmental Medicine, Unit of Lung Toxicology, K.U.Leuven, Leuven (Belgium)
  2. Departement of Chemistry, UA, Wilrijk (Belgium)
  3. Research group EnVOC, Department of Sustainable Organic Chemistry and Technology, UGent, Gent (Belgium)
  4. Royal Meteorological Institute, Brussels (Belgium)
Publication Date:
OSTI Identifier:
22157089
Resource Type:
Journal Article
Journal Name:
Environmental Research
Additional Journal Information:
Journal Volume: 117; Other Information: Copyright (c) 2012 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0013-9351
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; 60 APPLIED LIFE SCIENCES; BLOOD; BLOOD PRESSURE; CHRYSENE; CONCENTRATION RATIO; INDOOR AIR POLLUTION; IRON; NICKEL; POLYCYCLIC AROMATIC HYDROCARBONS; PULSES; PYRENE; TOBACCO SMOKES; VANADIUM

Citation Formats

Jacobs, Lotte, Buczynska, Anna, Walgraeve, Christophe, Delcloo, Andy, Potgieter-Vermaak, Sanja, Molecular Science Institute, School of Chemistry, University of Witwatersrand, Johannesburg, Division of Chemistry and Environmental Science, Manchester Metropolitan University, Manchester, Van Grieken, Rene, Demeestere, Kristof, Dewulf, Jo, Van Langenhove, Herman, De Backer, Hugo, Nemery, Benoit, Nawrot, Tim S., and Centre for Environmental Sciences, Hasselt University, Diepenbeek. Acute changes in pulse pressure in relation to constituents of particulate air pollution in elderly persons. United States: N. p., 2012. Web. doi:10.1016/J.ENVRES.2012.05.003.
Jacobs, Lotte, Buczynska, Anna, Walgraeve, Christophe, Delcloo, Andy, Potgieter-Vermaak, Sanja, Molecular Science Institute, School of Chemistry, University of Witwatersrand, Johannesburg, Division of Chemistry and Environmental Science, Manchester Metropolitan University, Manchester, Van Grieken, Rene, Demeestere, Kristof, Dewulf, Jo, Van Langenhove, Herman, De Backer, Hugo, Nemery, Benoit, Nawrot, Tim S., & Centre for Environmental Sciences, Hasselt University, Diepenbeek. Acute changes in pulse pressure in relation to constituents of particulate air pollution in elderly persons. United States. https://doi.org/10.1016/J.ENVRES.2012.05.003
Jacobs, Lotte, Buczynska, Anna, Walgraeve, Christophe, Delcloo, Andy, Potgieter-Vermaak, Sanja, Molecular Science Institute, School of Chemistry, University of Witwatersrand, Johannesburg, Division of Chemistry and Environmental Science, Manchester Metropolitan University, Manchester, Van Grieken, Rene, Demeestere, Kristof, Dewulf, Jo, Van Langenhove, Herman, De Backer, Hugo, Nemery, Benoit, Nawrot, Tim S., and Centre for Environmental Sciences, Hasselt University, Diepenbeek. 2012. "Acute changes in pulse pressure in relation to constituents of particulate air pollution in elderly persons". United States. https://doi.org/10.1016/J.ENVRES.2012.05.003.
@article{osti_22157089,
title = {Acute changes in pulse pressure in relation to constituents of particulate air pollution in elderly persons},
author = {Jacobs, Lotte and Buczynska, Anna and Walgraeve, Christophe and Delcloo, Andy and Potgieter-Vermaak, Sanja and Molecular Science Institute, School of Chemistry, University of Witwatersrand, Johannesburg and Division of Chemistry and Environmental Science, Manchester Metropolitan University, Manchester and Van Grieken, Rene and Demeestere, Kristof and Dewulf, Jo and Van Langenhove, Herman and De Backer, Hugo and Nemery, Benoit and Nawrot, Tim S. and Centre for Environmental Sciences, Hasselt University, Diepenbeek},
abstractNote = {An increased pulse pressure (difference between systolic and diastolic blood pressure) suggests aortic stiffening. The objective of this study was to examine the acute effects of both particulate matter (PM) mass and composition on blood pressure, among elderly persons. We carried out a panel study in persons living in elderly homes in Antwerp, Belgium. We recruited 88 non-smoking persons, 70% women with a mean age of 83 years (standard deviation: 5.2). Blood pressure was measured and a blood sample was collected on two time points, which were chosen so that there was an exposure contrast in ambient PM exposure. The elemental content of the collected indoor and outdoor PM{sub 2.5} (particulate matter with an aerodynamic diameter <2.5 {mu}m) mass concentration was measured. Oxygenated polycyclic aromatic hydrocarbons (oxy-PAHs) on outdoor PM{sub 10} (particulate matter with an aerodynamic diameter <10 {mu}m) were measured. Each interquartile range increase of 20.8 {mu}g/m Superscript-Three in 24-h mean outdoor PM{sub 2.5} was associated with an increase in pulse pressure of 4.0 mmHg (95% confidence interval: 1.8-6.2), in persons taking antihypertensive medication (n=57), but not in persons not using antihypertensive medication (n=31) (p for interaction: 0.02). Vanadium, iron and nickel contents of PM{sub 2.5} were significantly associated with systolic blood pressure and pulse pressure, among persons on antihypertensive medication. Similar results were found for indoor concentrations. Of the oxy-PAHs, chrysene-5,6-dione and benzo[a]pyrene-3,6-dione were significantly associated with increases in systolic blood pressure and pulse pressure. In elderly, pulse pressure was positively associated with acute increases in outdoor and indoor air pollution, among persons taking antihypertensive medication. These results might form a mechanistic pathway linking air pollution as a trigger of cardiovascular events.},
doi = {10.1016/J.ENVRES.2012.05.003},
url = {https://www.osti.gov/biblio/22157089}, journal = {Environmental Research},
issn = {0013-9351},
number = ,
volume = 117,
place = {United States},
year = {Wed Aug 15 00:00:00 EDT 2012},
month = {Wed Aug 15 00:00:00 EDT 2012}
}