skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: NRIP enhances HPV gene expression via interaction with either GR or E2

Abstract

We previously identified a gene, nuclear receptor-interaction protein (NRIP), which functions as a transcription cofactor in glucocorticoid receptor (GR) and human papillomavirus E2 (HPV E2)-driven gene expression. Here, we comprehensively evaluated the role of NRIP in HPV-16 gene expression. NRIP acts as a transcription cofactor to enhance GR-regulated HPV-16 gene expression in the presence of hormone. NRIP also can form complex with E2 that caused NRIP-induced HPV gene expression via E2-binding sites in a hormone-independent manner. Furthermore, NRIP can associate with GR and E2 to form tri-protein complex to activate HPV gene expression via GRE, not the E2-binding site, in a hormone-dependent manner. These results indicate that NRIP and GR are viral E2-binding proteins and that NRIP regulates HPV gene expression via GRE and/or E2 binding site in the HPV promoter in a hormone-dependent or independent manner, respectively.

Authors:
; ;  [1];  [2];  [3];  [1]
  1. Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei 100, Taiwan (China)
  2. Department of Microbiology and Immunology, National Chiayi University, Chiayi 600-04, Taiwan (China)
  3. Department of Ophthalmology, Mackay Memorial Hospital, Taipei 104, Taiwan (China)
Publication Date:
OSTI Identifier:
22149257
Resource Type:
Journal Article
Journal Name:
Virology
Additional Journal Information:
Journal Volume: 423; Journal Issue: 1; Other Information: Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0042-6822
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; GENES; GLUCOCORTICOIDS; PROMOTERS; RECEPTORS; TRANSCRIPTION

Citation Formats

Chang, Szu-Wei, Lu, Pei-Yu, Guo, Jih-Huong, Tsai, Tzung-Chieh, Tsao, Yeou-Ping, and Chen, Show-Li. NRIP enhances HPV gene expression via interaction with either GR or E2. United States: N. p., 2012. Web. doi:10.1016/J.VIROL.2011.11.015.
Chang, Szu-Wei, Lu, Pei-Yu, Guo, Jih-Huong, Tsai, Tzung-Chieh, Tsao, Yeou-Ping, & Chen, Show-Li. NRIP enhances HPV gene expression via interaction with either GR or E2. United States. https://doi.org/10.1016/J.VIROL.2011.11.015
Chang, Szu-Wei, Lu, Pei-Yu, Guo, Jih-Huong, Tsai, Tzung-Chieh, Tsao, Yeou-Ping, and Chen, Show-Li. 2012. "NRIP enhances HPV gene expression via interaction with either GR or E2". United States. https://doi.org/10.1016/J.VIROL.2011.11.015.
@article{osti_22149257,
title = {NRIP enhances HPV gene expression via interaction with either GR or E2},
author = {Chang, Szu-Wei and Lu, Pei-Yu and Guo, Jih-Huong and Tsai, Tzung-Chieh and Tsao, Yeou-Ping and Chen, Show-Li},
abstractNote = {We previously identified a gene, nuclear receptor-interaction protein (NRIP), which functions as a transcription cofactor in glucocorticoid receptor (GR) and human papillomavirus E2 (HPV E2)-driven gene expression. Here, we comprehensively evaluated the role of NRIP in HPV-16 gene expression. NRIP acts as a transcription cofactor to enhance GR-regulated HPV-16 gene expression in the presence of hormone. NRIP also can form complex with E2 that caused NRIP-induced HPV gene expression via E2-binding sites in a hormone-independent manner. Furthermore, NRIP can associate with GR and E2 to form tri-protein complex to activate HPV gene expression via GRE, not the E2-binding site, in a hormone-dependent manner. These results indicate that NRIP and GR are viral E2-binding proteins and that NRIP regulates HPV gene expression via GRE and/or E2 binding site in the HPV promoter in a hormone-dependent or independent manner, respectively.},
doi = {10.1016/J.VIROL.2011.11.015},
url = {https://www.osti.gov/biblio/22149257}, journal = {Virology},
issn = {0042-6822},
number = 1,
volume = 423,
place = {United States},
year = {Sun Feb 05 00:00:00 EST 2012},
month = {Sun Feb 05 00:00:00 EST 2012}
}