Correlations of urinary cadmium with hypertension and diabetes in persons living in cadmium-contaminated villages in northwestern Thailand: A population study

Swaddiwudhipong, Witaya; Mahasakpan, Pranee; Limpatanachote, Pisit; Krintratun, Somyot

doi:10.1016/J.ENVRES.2010.06.002

Title: Correlations of urinary cadmium with hypertension and diabetes in persons living in cadmium-contaminated villages in northwestern Thailand: A population study

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Abstract

Risk for hypertension and diabetes has not been conclusively found to be a result of cadmium exposure. A population-based study was conducted in 2009 to examine the correlations of urinary cadmium, a good biomarker of long-term cadmium exposure, with hypertension and diabetes in persons aged 35 years and older who lived in the 12 cadmium-contaminated rural villages in northwestern Thailand. A total of 5273 persons were interviewed and screened for urinary cadmium, hypertension, and diabetes. The geometric mean level of urinary cadmium for women (2.4{+-}2.3 {mu}g/g creatinine) was significantly greater than that for men (2.0{+-}2.2 {mu}g/g creatinine). Hypertension was presented in 29.8% of the study population and diabetes was detected in 6.6%. The prevalence of hypertension significantly increased from 25.0% among persons in the lowest tertile of urinary cadmium to 35.0% in the highest tertile. In women, the rate of hypertension significantly increased with increasing urinary cadmium levels in both ever and never smokers, after adjusting for age, alcohol consumption, body mass index, and diabetes. In men, such association was less significantly found in never smokers. The study revealed no significant association between urinary cadmium and diabetes in either gender. Our study supports the hypothesis that environmental exposure to cadmiummore »« less

Authors:

Swaddiwudhipong, Witaya ^[1]; Mahasakpan, Pranee ^[1]; Limpatanachote, Pisit; Krintratun, Somyot ^[2]

Department of Community and Social Medicine, Mae Sot General Hospital, Tak 63110 (Thailand)
Department of Internal Medicine, Mae Sot General Hospital, Tak (Thailand)

Publication Date:: Sun Aug 15 00:00:00 EDT 2010

OSTI Identifier:: 22149226

Resource Type:: Journal Article

Journal Name:: Environmental Research

Additional Journal Information:: Journal Volume: 110; Journal Issue: 6; Other Information: Copyright (c) 2010 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0013-9351

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES; ALCOHOLS; BIOLOGICAL MARKERS; CADMIUM; CREATININE; ENVIRONMENTAL EXPOSURE; HEALTH HAZARDS; HYPERTENSION; TOBACCO SMOKES

Citation Formats


                    Swaddiwudhipong, Witaya, Mahasakpan, Pranee, Limpatanachote, Pisit, and Krintratun, Somyot. Correlations of urinary cadmium with hypertension and diabetes in persons living in cadmium-contaminated villages in northwestern Thailand: A population study.  United States: N. p., 2010. 
        Web.  doi:10.1016/J.ENVRES.2010.06.002.

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                    Swaddiwudhipong, Witaya, Mahasakpan, Pranee, Limpatanachote, Pisit, & Krintratun, Somyot. Correlations of urinary cadmium with hypertension and diabetes in persons living in cadmium-contaminated villages in northwestern Thailand: A population study.  United States.  https://doi.org/10.1016/J.ENVRES.2010.06.002

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                    Swaddiwudhipong, Witaya, Mahasakpan, Pranee, Limpatanachote, Pisit, and Krintratun, Somyot. 2010.  
        "Correlations of urinary cadmium with hypertension and diabetes in persons living in cadmium-contaminated villages in northwestern Thailand: A population study".  United States.  https://doi.org/10.1016/J.ENVRES.2010.06.002.

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@article{osti_22149226,

  title        = {Correlations of urinary cadmium with hypertension and diabetes in persons living in cadmium-contaminated villages in northwestern Thailand: A population study},

  author       = {Swaddiwudhipong, Witaya and Mahasakpan, Pranee and Limpatanachote, Pisit and Krintratun, Somyot},

  abstractNote = {Risk for hypertension and diabetes has not been conclusively found to be a result of cadmium exposure. A population-based study was conducted in 2009 to examine the correlations of urinary cadmium, a good biomarker of long-term cadmium exposure, with hypertension and diabetes in persons aged 35 years and older who lived in the 12 cadmium-contaminated rural villages in northwestern Thailand. A total of 5273 persons were interviewed and screened for urinary cadmium, hypertension, and diabetes. The geometric mean level of urinary cadmium for women (2.4{+-}2.3 {mu}g/g creatinine) was significantly greater than that for men (2.0{+-}2.2 {mu}g/g creatinine). Hypertension was presented in 29.8% of the study population and diabetes was detected in 6.6%. The prevalence of hypertension significantly increased from 25.0% among persons in the lowest tertile of urinary cadmium to 35.0% in the highest tertile. In women, the rate of hypertension significantly increased with increasing urinary cadmium levels in both ever and never smokers, after adjusting for age, alcohol consumption, body mass index, and diabetes. In men, such association was less significantly found in never smokers. The study revealed no significant association between urinary cadmium and diabetes in either gender. Our study supports the hypothesis that environmental exposure to cadmium may increase the risk of hypertension. Risk for diabetes in relation to cadmium exposure remains uncertain in this exposed population.},

  doi          = {10.1016/J.ENVRES.2010.06.002},

  url          = {https://www.osti.gov/biblio/22149226},
  journal      = {Environmental Research},

  issn         = {0013-9351},

  number       = 6,

  volume       = 110,

  place        = {United States},

  year         = {Sun Aug 15 00:00:00 EDT 2010},

  month        = {Sun Aug 15 00:00:00 EDT 2010}

}

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