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Title: Microplasma source for optogalvanic spectroscopy of nanogram samples

The demand for analysis of smaller samples in isotopic ratio measurements of rare isotopes is continuously rising with the development of new applications, particularly in biomedicine. Interesting in this aspect are methods based on optogalvanic spectroscopy, which have been reported to facilitate both {sup 13}C-to-{sup 12}C and {sup 14}C-to-{sup 12}C ratio measurements with high sensitivity. These methods also facilitate analysis of very small samples, down to the microgram range, which makes them very competitive to other technologies, e.g., accelerator mass spectroscopy. However, there exists a demand for moving beyond the microgram range, especially from regenerative medicine, where samples consist of, e.g., DNA, and, hence, the total sample amount is extremely small. Making optogalvanic spectroscopy of carbon isotopes applicable to such small samples, requires miniaturization of the key component of the system, namely the plasma source, in which the sample is ionized before analysis. In this paper, a novel design of such a microplasma source based on a stripline split-ring resonator is presented and evaluated in a basic optogalvanic spectrometer. The investigations focus on the capability of the plasma source to measure the optogalvanic signal in general, and the effect of different system and device specific parameters on the amplitude andmore » stability of the optogalvanic signal in particular. Different sources of noise and instabilities are identified, and methods of mitigating these issues are discussed. Finally, the ability of the cell to handle analysis of samples down to the nanogram range is investigated, pinpointing the great prospects of stripline split-ring resonators in optogalvanic spectroscopy.« less
Authors:
;  [1] ;  [1] ;  [2]
  1. Angstroem Space Technology Centre, Department of Engineering Sciences, Uppsala University, Box 534, SE-75121 Uppsala (Sweden)
  2. (Sweden)
Publication Date:
OSTI Identifier:
22122836
Resource Type:
Journal Article
Resource Relation:
Journal Name: Journal of Applied Physics; Journal Volume: 114; Journal Issue: 3; Other Information: (c) 2013 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS; ACCELERATORS; AMPLITUDES; CARBON 12; CARBON 13; CARBON 14; ISOTOPE RATIO; MASS SPECTROSCOPY; MINIATURIZATION; NANOSTRUCTURES; PLASMA; PLASMA INSTABILITY; RESONATORS; SENSITIVITY; SPECTROMETERS; STABILITY