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Title: Radioembolization of the Spleen: A Revisited Approach for the Treatment of Malignant Lymphomatous Splenomegaly

Intraarterial administration of {sup 90}Y microspheres to the spleen in patients with malignant lymphoma was mentioned once in the literature in 1973. This case study illustrates the potential indication of selective internal radiotherapy in a heavily pretreated patient with highly refractory disease with a marginal zone lymphoma in leukemic phase and symptomatic splenomegaly. We describe the clinical course of disease; the biological and clinical response to the treatment after radioembolization; and simulation and dosimetry by multimodal imaging via single-photon emission computed tomography and computed tomography. The advantages of radioembolization for the management of lymphomatous splenomegaly are discussed.
Authors:
 [1] ;  [2] ;  [3] ;  [2] ;  [4] ;  [5] ;  [6] ;  [7] ;  [2] ;  [1]
  1. Jules Bordet Institute, ULB, Department of Nuclear Medicine (Belgium)
  2. Jules Bordet Institute, ULB, Department of Haematology (Belgium)
  3. Jules Bordet Institute, ULB, Department of Anatomo-Pathology (Belgium)
  4. UMC Sint-Pieter, Department of Interventional Radiology (Belgium)
  5. Jules Bordet Institute, ULB, Department of Radiophysics (Belgium)
  6. Jules Bordet Institute, ULB, Department of Radiotherapy (Belgium)
  7. Jules Bordet Institute, ULB, Department of Radiology (Belgium)
Publication Date:
OSTI Identifier:
22121751
Resource Type:
Journal Article
Resource Relation:
Journal Name: Cardiovascular and Interventional Radiology; Journal Volume: 36; Journal Issue: 4; Other Information: Copyright (c) 2013 Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); Article Copyright (c) 2012 Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; DOSIMETRY; LYMPHOMAS; MICROSPHERES; PATIENTS; RADIOTHERAPY; SIMULATION; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; SPLEEN; SPLENOMEGALY; YTTRIUM 90