Aperture modulated, translating bed total body irradiation

Journal Article · Tue Feb 15 00:00:00 EST 2011 · Medical Physics

DOI:https://doi.org/10.1118/1.3534196· OSTI ID:22098535

Hussain, Amjad; Villarreal-Barajas, Jose Eduardo; Dunscombe, Peter; Brown, Derek W. ^[1]

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1. Department of Medical Physics, Tom Baker Cancer Centre, Calgary, Alberta T2N 4N2 (Canada)

Purpose: Total body irradiation (TBI) techniques aim to deliver a uniform radiation dose to a patient with an irregular body contour and a heterogeneous density distribution to within {+-}10% of the prescribed dose. In the current article, the authors present a novel, aperture modulated, translating bed TBI (AMTBI) technique that produces a high degree of dose uniformity throughout the entire patient. Methods: The radiation beam is dynamically shaped in two dimensions using a multileaf collimator (MLC). The irregular surface compensation algorithm in the Eclipse treatment planning system is used for fluence optimization, which is performed based on penetration depth and internal inhomogeneities. Two optimal fluence maps (AP and PA) are generated and beam apertures are created to deliver these optimal fluences. During treatment, the patient/phantom is translated on a motorized bed close to the floor (source to bed distance: 204.5 cm) under a stationary radiation beam with 0 deg. gantry angle. The bed motion and dynamic beam apertures are synchronized. Results: The AMTBI technique produces a more homogeneous dose distribution than fixed open beam translating bed TBI. In phantom studies, the dose deviation along the midline is reduced from 10% to less than 5% of the prescribed dose in the longitudinal direction. Dose to the lung is reduced by more than 15% compared to the unshielded fixed open beam technique. At the lateral body edges, the dose received from the open beam technique was 20% higher than that prescribed at umbilicus midplane. With AMTBI the dose deviation in this same region is reduced to less than 3% of the prescribed dose. Validation of the technique was performed using thermoluminescent dosimeters in a Rando phantom. Agreement between calculation and measurement was better than 3% in all cases. Conclusions: A novel, translating bed, aperture modulated TBI technique that employs dynamically shaped MLC defined beams is shown to improve dose uniformity in three dimensions. In comparison with the fixed open beam TBI technique, homogeneity of dose distribution is greatly improved.

• OSTI ID: 22098535
• Journal Information: Medical Physics, Vol. 38, Issue 2; Other Information: (c) 2011 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA); ISSN 0094-2405
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
61 RADIATION PROTECTION AND DOSIMETRY
ALGORITHMS
APERTURES
BEAMS
COLLIMATORS
COMPARATIVE EVALUATIONS
COMPUTERIZED TOMOGRAPHY
LUNGS
OPTIMIZATION
PATIENTS
PENETRATION DEPTH
PHANTOMS
RADIATION DOSE DISTRIBUTIONS
RADIATION DOSES
RADIOTHERAPY
THERMOLUMINESCENT DOSEMETERS
VALIDATION
WHOLE-BODY IRRADIATION