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Title: PET/CT in radiation oncology

Abstract

PET/CT is an effective tool for the diagnosis, staging and restaging of cancer patients. It combines the complementary information of functional PET images and anatomical CT images in one imaging session. Conventional stand-alone PET has been replaced by PET/CT for improved patient comfort, patient throughput, and most importantly the proven clinical outcome of PET/CT over that of PET and that of separate PET and CT. There are over two thousand PET/CT scanners installed worldwide since 2001. Oncology is the main application for PET/CT. Fluorine-18 deoxyglucose is the choice of radiopharmaceutical in PET for imaging the glucose uptake in tissues, correlated with an increased rate of glycolysis in many tumor cells. New molecular targeted agents are being developed to improve the accuracy of targeting different disease states and assessing therapeutic response. Over 50% of cancer patients receive radiation therapy (RT) in the course of their disease treatment. Clinical data have demonstrated that the information provided by PET/CT often changes patient management of the patient and/or modifies the RT plan from conventional CT simulation. The application of PET/CT in RT is growing and will become increasingly important. Continuing improvement of PET/CT instrumentation will also make it easier for radiation oncologists to integratemore » PET/CT in RT. The purpose of this article is to provide a review of the current PET/CT technology, to project the future development of PET and CT for PET/CT, and to discuss some issues in adopting PET/CT in RT and potential improvements in PET/CT simulation of the thorax in radiation therapy.« less

Authors:
;  [1]
  1. Department of Imaging Physics, M. D. Anderson Cancer Center, University of Texas, Houston, Texas 77030 (United States)
Publication Date:
OSTI Identifier:
22095248
Resource Type:
Journal Article
Journal Name:
Medical Physics
Additional Journal Information:
Journal Volume: 35; Journal Issue: 11; Other Information: (c) 2008 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0094-2405
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BIOCHEMISTRY; BIOPHYSICS; CAT SCANNING; FLUORINE 18; GLUCOSE; GLYCOLYSIS; NEOPLASMS; PATIENTS; POSITRON COMPUTED TOMOGRAPHY; RADIOPHARMACEUTICALS; RADIOTHERAPY; TUMOR CELLS

Citation Formats

Pan, Tinsu, and Mawlawi, Osama. PET/CT in radiation oncology. United States: N. p., 2008. Web. doi:10.1118/1.2986145.
Pan, Tinsu, & Mawlawi, Osama. PET/CT in radiation oncology. United States. https://doi.org/10.1118/1.2986145
Pan, Tinsu, and Mawlawi, Osama. 2008. "PET/CT in radiation oncology". United States. https://doi.org/10.1118/1.2986145.
@article{osti_22095248,
title = {PET/CT in radiation oncology},
author = {Pan, Tinsu and Mawlawi, Osama},
abstractNote = {PET/CT is an effective tool for the diagnosis, staging and restaging of cancer patients. It combines the complementary information of functional PET images and anatomical CT images in one imaging session. Conventional stand-alone PET has been replaced by PET/CT for improved patient comfort, patient throughput, and most importantly the proven clinical outcome of PET/CT over that of PET and that of separate PET and CT. There are over two thousand PET/CT scanners installed worldwide since 2001. Oncology is the main application for PET/CT. Fluorine-18 deoxyglucose is the choice of radiopharmaceutical in PET for imaging the glucose uptake in tissues, correlated with an increased rate of glycolysis in many tumor cells. New molecular targeted agents are being developed to improve the accuracy of targeting different disease states and assessing therapeutic response. Over 50% of cancer patients receive radiation therapy (RT) in the course of their disease treatment. Clinical data have demonstrated that the information provided by PET/CT often changes patient management of the patient and/or modifies the RT plan from conventional CT simulation. The application of PET/CT in RT is growing and will become increasingly important. Continuing improvement of PET/CT instrumentation will also make it easier for radiation oncologists to integrate PET/CT in RT. The purpose of this article is to provide a review of the current PET/CT technology, to project the future development of PET and CT for PET/CT, and to discuss some issues in adopting PET/CT in RT and potential improvements in PET/CT simulation of the thorax in radiation therapy.},
doi = {10.1118/1.2986145},
url = {https://www.osti.gov/biblio/22095248}, journal = {Medical Physics},
issn = {0094-2405},
number = 11,
volume = 35,
place = {United States},
year = {Sat Nov 15 00:00:00 EST 2008},
month = {Sat Nov 15 00:00:00 EST 2008}
}