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Title: Role of Intra- or Periprostatic Calcifications in Image-Guided Radiotherapy for Prostate Cancer

Abstract

Purpose: Image-guided radiotherapy (IGRT) allows more precise localization of the prostate, thus minimizing errors resulting from organ motion and set-up during treatment of prostate cancer. Using megavoltage cone-beam computed tomography (MVCBCT), references such as bones, the prostate itself or implanted fiducial markers can be used as surrogates to correct patient positioning immediately before each treatment fraction. However, the use of fiducials requires an invasive procedure and may increase costs. We aimed to assess whether intra- or periprostatic calcifications (IPC) could be used as natural fiducials. Methods and Materials: Data on patients treated with IGRT for prostate cancer with clearly visible IPC and implanted fiducials in both planning CT and MVCBCT images were reviewed. IPC were classified as central when inside the prostate and peripheral when within the planning target volume. Daily deviations in lateral, longitudinal, and vertical directions from baseline positioning using fiducials and using IPC were compared. Results: A total of 287 MVCBCT images were obtained and analyzed from 10 patients. The mean {+-} standard deviation daily deviation (mm) in the lateral, longitudinal, and vertical coordinates were 0.55 {+-} 3.11, 0.58 {+-} 3.45, and -0.54 {+-} 4.03, respectively, for fiducials, and 0.72 {+-} 3.22, 0.63 {+-} 3.58, and -0.69more » {+-} 4.26, for IPC. The p values for comparisons (fiducials vs. IPC) were 0.003, 0.653, and 0.078 for lateral, longitudinal, and vertical coordinates, respectively. When cases with central IPC were analyzed (n = 7), no significant difference was found in such comparisons. Central IPC and fiducials exhibited a similar pattern of displacement during treatment, with equal values for daily displacements in the three directions for more than 90% of measurements. Conclusions: Our data suggest that centrally located IPC may be used as natural fiducials for treatment positioning during IGRT for prostate cancer, with potential reductions in the risks and costs associated with fiducial implantation.« less

Authors:
; ; ;  [1]
  1. Department of Radiotherapy, Hospital Sirio-Libanes, Sao Paulo (Brazil)
Publication Date:
OSTI Identifier:
22056119
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 82; Journal Issue: 3; Other Information: Copyright (c) 2012 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; COMPUTERIZED TOMOGRAPHY; HAZARDS; IMAGES; NEOPLASMS; PATIENTS; PLANNING; PROSTATE; RADIOTHERAPY; SKELETON

Citation Formats

Hanna, Samir Abdallah, E-mail: samir.hanna@hsl.org.br, Neves-Junior, Wellington Furtado Pimenta, Marta, Gustavo Nader, Haddad, Cecilia Maria Kalil, and Fernandes da Silva, Joao Luis. Role of Intra- or Periprostatic Calcifications in Image-Guided Radiotherapy for Prostate Cancer. United States: N. p., 2012. Web. doi:10.1016/J.IJROBP.2011.03.059.
Hanna, Samir Abdallah, E-mail: samir.hanna@hsl.org.br, Neves-Junior, Wellington Furtado Pimenta, Marta, Gustavo Nader, Haddad, Cecilia Maria Kalil, & Fernandes da Silva, Joao Luis. Role of Intra- or Periprostatic Calcifications in Image-Guided Radiotherapy for Prostate Cancer. United States. https://doi.org/10.1016/J.IJROBP.2011.03.059
Hanna, Samir Abdallah, E-mail: samir.hanna@hsl.org.br, Neves-Junior, Wellington Furtado Pimenta, Marta, Gustavo Nader, Haddad, Cecilia Maria Kalil, and Fernandes da Silva, Joao Luis. 2012. "Role of Intra- or Periprostatic Calcifications in Image-Guided Radiotherapy for Prostate Cancer". United States. https://doi.org/10.1016/J.IJROBP.2011.03.059.
@article{osti_22056119,
title = {Role of Intra- or Periprostatic Calcifications in Image-Guided Radiotherapy for Prostate Cancer},
author = {Hanna, Samir Abdallah, E-mail: samir.hanna@hsl.org.br and Neves-Junior, Wellington Furtado Pimenta and Marta, Gustavo Nader and Haddad, Cecilia Maria Kalil and Fernandes da Silva, Joao Luis},
abstractNote = {Purpose: Image-guided radiotherapy (IGRT) allows more precise localization of the prostate, thus minimizing errors resulting from organ motion and set-up during treatment of prostate cancer. Using megavoltage cone-beam computed tomography (MVCBCT), references such as bones, the prostate itself or implanted fiducial markers can be used as surrogates to correct patient positioning immediately before each treatment fraction. However, the use of fiducials requires an invasive procedure and may increase costs. We aimed to assess whether intra- or periprostatic calcifications (IPC) could be used as natural fiducials. Methods and Materials: Data on patients treated with IGRT for prostate cancer with clearly visible IPC and implanted fiducials in both planning CT and MVCBCT images were reviewed. IPC were classified as central when inside the prostate and peripheral when within the planning target volume. Daily deviations in lateral, longitudinal, and vertical directions from baseline positioning using fiducials and using IPC were compared. Results: A total of 287 MVCBCT images were obtained and analyzed from 10 patients. The mean {+-} standard deviation daily deviation (mm) in the lateral, longitudinal, and vertical coordinates were 0.55 {+-} 3.11, 0.58 {+-} 3.45, and -0.54 {+-} 4.03, respectively, for fiducials, and 0.72 {+-} 3.22, 0.63 {+-} 3.58, and -0.69 {+-} 4.26, for IPC. The p values for comparisons (fiducials vs. IPC) were 0.003, 0.653, and 0.078 for lateral, longitudinal, and vertical coordinates, respectively. When cases with central IPC were analyzed (n = 7), no significant difference was found in such comparisons. Central IPC and fiducials exhibited a similar pattern of displacement during treatment, with equal values for daily displacements in the three directions for more than 90% of measurements. Conclusions: Our data suggest that centrally located IPC may be used as natural fiducials for treatment positioning during IGRT for prostate cancer, with potential reductions in the risks and costs associated with fiducial implantation.},
doi = {10.1016/J.IJROBP.2011.03.059},
url = {https://www.osti.gov/biblio/22056119}, journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 3,
volume = 82,
place = {United States},
year = {Thu Mar 01 00:00:00 EST 2012},
month = {Thu Mar 01 00:00:00 EST 2012}
}