Failure to Adhere to Protocol Specified Radiation Therapy Guidelines Was Associated With Decreased Survival in RTOG 9704-A Phase III Trial of Adjuvant Chemotherapy and Chemoradiotherapy for Patients With Resected Adenocarcinoma of the Pancreas

Journal Article · Wed Feb 01 00:00:00 EST 2012 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/J.IJROBP.2010.11.039· OSTI ID:22056038

Winter, Kathryn A ^[1]; Regine, William F ^[2]; Safran, Howard ^[3]; Hoffman, John P ^[4]; Lustig, Robert ^[1]; Konski, Andre A ^[5]; Benson, Al B ^[6]; Macdonald, John S ^[7]; Rich, Tyvin A ^[8]; Willett, Christopher G ^[9]

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1. Radiation Therapy Oncology Group Statistical Center, Philadelphia, PA (United States)
2. University of Maryland, Baltimore, MD (United States)
3. Brown University, Providence, RI (United States)
4. Fox Chase Cancer Center, Philadelphia, PA (United States)
5. Wayne State Medical Center, Detroit, MI (United States)
6. Northwestern University, Chicago, IL (United States)
7. St. Vincent's Cancer Care Center, New York, NY (United States)
8. University of Virginia, Charlottesville, VA (United States)
9. Duke University, Durham, NC (United States)

Purpose: In Radiation Therapy Oncology Group 9704, as previously published, patients with resected pancreatic adenocarcinoma received continuous infusion 5-FU and concurrent radiotherapy (5FU-RT). 5FU-RT treatment was preceded and followed by randomly assigned chemotherapy, either 5-FU or gemcitabine. This analysis explored whether failure to adhere to specified RT guidelines influenced survival and/or toxicity. Methods and Materials: RT requirements were protocol specified. Adherence was scored as per protocol (PP) or less than per protocol (

• OSTI ID: 22056038
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Vol. 82, Issue 2; Other Information: Copyright (c) 2012 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CARCINOMAS
CHEMOTHERAPY
COMBINED THERAPY
FAILURES
HAZARDS
HEAD
INFUSION
MULTIVARIATE ANALYSIS
PANCREAS
PATIENTS
QUALITY ASSURANCE
RADIOTHERAPY
RECOMMENDATIONS
TOXICITY