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Title: Shorter-Course Whole-Brain Radiotherapy for Brain Metastases in Elderly Patients

Abstract

Purpose: Many patients with brain metastases receive whole-brain radiotherapy (WBRT) alone. Using 10 Multiplication-Sign 3 Gy in 2 weeks is the standard regimen in most centers. Regarding the extraordinarily poor survival prognosis of elderly patients with multiple brain metastases, a shorter WBRT regimen would be preferable. This study compared 10 Multiplication-Sign 3 Gy with 5 Multiplication-Sign 4 Gy in elderly patients ({>=}65 years). Methods and Materials: Data from 455 elderly patients who received WBRT alone for brain metastases were retrospectively analyzed. Survival and local (= intracerebral) control of 293 patients receiving 10 Multiplication-Sign 3 Gy were compared with 162 patients receiving 5 Multiplication-Sign 4 Gy. Eight additional potential prognostic factors were investigated including age, gender, Karnofsky performance score (KPS), primary tumor, number of brain metastases, interval from tumor diagnosis to WBRT, extracerebral metastases, and recursive partitioning analysis (RPA) class. Results: The 6-month overall survival rates were 29% after 5 Multiplication-Sign 4 Gy and 21% after 10 Multiplication-Sign 3 Gy (p = 0.020). The 6-month local control rates were 12% and 10%, respectively (p = 0.32). On multivariate analysis, improved overall survival was associated with KPS {>=} 70 (p < 0.001), only one to three brain metastases (p = 0.029), nomore » extracerebral metastasis (p = 0.012), and lower RPA class (p < 0.001). Improved local control was associated with KPS {>=} 70 (p < 0.001), breast cancer (p = 0.029), and lower RPA class (p < 0.001). Conclusions: Shorter-course WBRT with 5 Multiplication-Sign 4 Gy was not inferior to 10 Multiplication-Sign 3 Gy with respect to overall survival or local control in elderly patients. 5 Multiplication-Sign 4 Gy appears preferable for the majority of these patients.« less

Authors:
 [1];  [1];  [2];  [3];  [4];  [5]
  1. Department of Radiation Oncology, University Hospital Schleswig-Holstein, Lubeck (Germany)
  2. Department of Radiotherapy, Dr. Bernard Verbeeten Institute, Tilburg (Netherlands)
  3. Department of Radiotherapy, Academic Medical Center, Amsterdam (Netherlands)
  4. Department of Radiation Oncology, University Hospital, Prague (Czech Republic)
  5. Department of Radiation Oncology, Mayo Clinic Scottsdale, Arizona (United States)
Publication Date:
OSTI Identifier:
22054414
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 81; Journal Issue: 4; Other Information: Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BRAIN; DIAGNOSIS; MAMMARY GLANDS; METASTASES; MULTIVARIATE ANALYSIS; NEOPLASMS; PATIENTS; PERFORMANCE; RADIOTHERAPY

Citation Formats

Rades, Dirk, Department of Radiation Oncology, University Hospital Hamburg-Eppendorf, Hamburg, Evers, Jasmin N, Veninga, Theo, Stalpers, Lukas J.A., Lohynska, Radka, and Schild, Steven E. Shorter-Course Whole-Brain Radiotherapy for Brain Metastases in Elderly Patients. United States: N. p., 2011. Web. doi:10.1016/J.IJROBP.2011.01.058.
Rades, Dirk, Department of Radiation Oncology, University Hospital Hamburg-Eppendorf, Hamburg, Evers, Jasmin N, Veninga, Theo, Stalpers, Lukas J.A., Lohynska, Radka, & Schild, Steven E. Shorter-Course Whole-Brain Radiotherapy for Brain Metastases in Elderly Patients. United States. https://doi.org/10.1016/J.IJROBP.2011.01.058
Rades, Dirk, Department of Radiation Oncology, University Hospital Hamburg-Eppendorf, Hamburg, Evers, Jasmin N, Veninga, Theo, Stalpers, Lukas J.A., Lohynska, Radka, and Schild, Steven E. 2011. "Shorter-Course Whole-Brain Radiotherapy for Brain Metastases in Elderly Patients". United States. https://doi.org/10.1016/J.IJROBP.2011.01.058.
@article{osti_22054414,
title = {Shorter-Course Whole-Brain Radiotherapy for Brain Metastases in Elderly Patients},
author = {Rades, Dirk and Department of Radiation Oncology, University Hospital Hamburg-Eppendorf, Hamburg and Evers, Jasmin N and Veninga, Theo and Stalpers, Lukas J.A. and Lohynska, Radka and Schild, Steven E},
abstractNote = {Purpose: Many patients with brain metastases receive whole-brain radiotherapy (WBRT) alone. Using 10 Multiplication-Sign 3 Gy in 2 weeks is the standard regimen in most centers. Regarding the extraordinarily poor survival prognosis of elderly patients with multiple brain metastases, a shorter WBRT regimen would be preferable. This study compared 10 Multiplication-Sign 3 Gy with 5 Multiplication-Sign 4 Gy in elderly patients ({>=}65 years). Methods and Materials: Data from 455 elderly patients who received WBRT alone for brain metastases were retrospectively analyzed. Survival and local (= intracerebral) control of 293 patients receiving 10 Multiplication-Sign 3 Gy were compared with 162 patients receiving 5 Multiplication-Sign 4 Gy. Eight additional potential prognostic factors were investigated including age, gender, Karnofsky performance score (KPS), primary tumor, number of brain metastases, interval from tumor diagnosis to WBRT, extracerebral metastases, and recursive partitioning analysis (RPA) class. Results: The 6-month overall survival rates were 29% after 5 Multiplication-Sign 4 Gy and 21% after 10 Multiplication-Sign 3 Gy (p = 0.020). The 6-month local control rates were 12% and 10%, respectively (p = 0.32). On multivariate analysis, improved overall survival was associated with KPS {>=} 70 (p < 0.001), only one to three brain metastases (p = 0.029), no extracerebral metastasis (p = 0.012), and lower RPA class (p < 0.001). Improved local control was associated with KPS {>=} 70 (p < 0.001), breast cancer (p = 0.029), and lower RPA class (p < 0.001). Conclusions: Shorter-course WBRT with 5 Multiplication-Sign 4 Gy was not inferior to 10 Multiplication-Sign 3 Gy with respect to overall survival or local control in elderly patients. 5 Multiplication-Sign 4 Gy appears preferable for the majority of these patients.},
doi = {10.1016/J.IJROBP.2011.01.058},
url = {https://www.osti.gov/biblio/22054414}, journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 4,
volume = 81,
place = {United States},
year = {Tue Nov 15 00:00:00 EST 2011},
month = {Tue Nov 15 00:00:00 EST 2011}
}