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Title: The DRAGO gamma camera

Abstract

In this work, we present the results of the experimental characterization of the DRAGO (DRift detector Array-based Gamma camera for Oncology), a detection system developed for high-spatial resolution gamma-ray imaging. This camera is based on a monolithic array of 77 silicon drift detectors (SDDs), with a total active area of 6.7 cm{sup 2}, coupled to a single 5-mm-thick CsI(Tl) scintillator crystal. The use of an array of SDDs provides a high quantum efficiency for the detection of the scintillation light together with a very low electronics noise. A very compact detection module based on the use of integrated readout circuits was developed. The performances achieved in gamma-ray imaging using this camera are reported here. When imaging a 0.2 mm collimated {sup 57}Co source (122 keV) over different points of the active area, a spatial resolution ranging from 0.25 to 0.5 mm was measured. The depth-of-interaction capability of the detector, thanks to the use of a Maximum Likelihood reconstruction algorithm, was also investigated by imaging a collimated beam tilted to an angle of 45 deg. with respect to the scintillator surface. Finally, the imager was characterized with in vivo measurements on mice, in a real preclinical environment.

Authors:
; ; ;  [1]; ;  [2];  [3]; ; ;  [4];  [5];  [6]
  1. Dipartimento di Elettronica e Informazione, Politecnico di Milano, Milano 20133, Italy and INFN, Sezione di Milano, Milano 20133 (Italy)
  2. PNSensor GmbH and PNDetector GmbH, D-80803 Munich (Germany)
  3. Max Planck Institut Halbleiterlabor, D-81739 Munich (Germany)
  4. Department of Biomedical Sciences and Technologies, University of Milan, Milano 20133, Italy and Centre of Molecular and Cellular Imaging-IMAGO, Milano (Italy)
  5. Department of Medicine, Surgery, and Dentistry, University of Milan, Milano 20142 (Italy)
  6. IBFM-CNR, Istituto Scientifico Ospedale San Raffale, Milano 20132 (Italy)
Publication Date:
OSTI Identifier:
22053982
Resource Type:
Journal Article
Journal Name:
Review of Scientific Instruments
Additional Journal Information:
Journal Volume: 81; Journal Issue: 4; Other Information: (c) 2010 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0034-6748
Country of Publication:
United States
Language:
English
Subject:
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY; 62 RADIOLOGY AND NUCLEAR MEDICINE; ALGORITHMS; BEAMS; CESIUM IODIDES; COBALT 57; GAMMA CAMERAS; GAMMA DETECTION; IN VIVO; KEV RANGE; LI-DRIFTED SI DETECTORS; MAXIMUM-LIKELIHOOD FIT; MICE; QUANTUM EFFICIENCY; READOUT SYSTEMS; SCINTILLATIONS; SOLID SCINTILLATION DETECTORS; SPATIAL RESOLUTION; VISIBLE RADIATION

Citation Formats

Fiorini, C, Gola, A, Peloso, R, Longoni, A, Lechner, P, Soltau, H, Strueder, L, Ottobrini, L, Martelli, C, Lui, R, Madaschi, L, and Belloli, S. The DRAGO gamma camera. United States: N. p., 2010. Web. doi:10.1063/1.3378686.
Fiorini, C, Gola, A, Peloso, R, Longoni, A, Lechner, P, Soltau, H, Strueder, L, Ottobrini, L, Martelli, C, Lui, R, Madaschi, L, & Belloli, S. The DRAGO gamma camera. United States. https://doi.org/10.1063/1.3378686
Fiorini, C, Gola, A, Peloso, R, Longoni, A, Lechner, P, Soltau, H, Strueder, L, Ottobrini, L, Martelli, C, Lui, R, Madaschi, L, and Belloli, S. 2010. "The DRAGO gamma camera". United States. https://doi.org/10.1063/1.3378686.
@article{osti_22053982,
title = {The DRAGO gamma camera},
author = {Fiorini, C and Gola, A and Peloso, R and Longoni, A and Lechner, P and Soltau, H and Strueder, L and Ottobrini, L and Martelli, C and Lui, R and Madaschi, L and Belloli, S},
abstractNote = {In this work, we present the results of the experimental characterization of the DRAGO (DRift detector Array-based Gamma camera for Oncology), a detection system developed for high-spatial resolution gamma-ray imaging. This camera is based on a monolithic array of 77 silicon drift detectors (SDDs), with a total active area of 6.7 cm{sup 2}, coupled to a single 5-mm-thick CsI(Tl) scintillator crystal. The use of an array of SDDs provides a high quantum efficiency for the detection of the scintillation light together with a very low electronics noise. A very compact detection module based on the use of integrated readout circuits was developed. The performances achieved in gamma-ray imaging using this camera are reported here. When imaging a 0.2 mm collimated {sup 57}Co source (122 keV) over different points of the active area, a spatial resolution ranging from 0.25 to 0.5 mm was measured. The depth-of-interaction capability of the detector, thanks to the use of a Maximum Likelihood reconstruction algorithm, was also investigated by imaging a collimated beam tilted to an angle of 45 deg. with respect to the scintillator surface. Finally, the imager was characterized with in vivo measurements on mice, in a real preclinical environment.},
doi = {10.1063/1.3378686},
url = {https://www.osti.gov/biblio/22053982}, journal = {Review of Scientific Instruments},
issn = {0034-6748},
number = 4,
volume = 81,
place = {United States},
year = {Thu Apr 15 00:00:00 EDT 2010},
month = {Thu Apr 15 00:00:00 EDT 2010}
}