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Title: Oxidative stress and oxidative damage in chemical carcinogenesis

Abstract

Reactive oxygen species (ROS) are induced through a variety of endogenous and exogenous sources. Overwhelming of antioxidant and DNA repair mechanisms in the cell by ROS may result in oxidative stress and oxidative damage to the cell. This resulting oxidative stress can damage critical cellular macromolecules and/or modulate gene expression pathways. Cancer induction by chemical and physical agents involves a multi-step process. This process includes multiple molecular and cellular events to transform a normal cell to a malignant neoplastic cell. Oxidative damage resulting from ROS generation can participate in all stages of the cancer process. An association of ROS generation and human cancer induction has been shown. It appears that oxidative stress may both cause as well as modify the cancer process. Recently association between polymorphisms in oxidative DNA repair genes and antioxidant genes (single nucleotide polymorphisms) and human cancer susceptibility has been shown.

Authors:
; ;
Publication Date:
OSTI Identifier:
21587794
Resource Type:
Journal Article
Journal Name:
Toxicology and Applied Pharmacology
Additional Journal Information:
Journal Volume: 254; Journal Issue: 2; Conference: TRAC 2008/2009 meeting: 2008 Toxicology and Risk Assessment Conference;2009 Toxicology and Risk Assessment Conference, West Chester, OH (United States);West Chester, OH (United States), 14-17 Apr 2008;27-30 Apr 2009; Other Information: DOI: 10.1016/j.taap.2009.11.028; PII: S0041-008X(11)00045-7; Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0041-008X
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ANTIOXIDANTS; CARCINOGENESIS; DAMAGE; DNA DAMAGES; DNA REPAIR; GENES; HUMAN POPULATIONS; NEOPLASMS; NUCLEOTIDES; OXIDATION; OXYGEN; STRESSES; BIOLOGICAL RECOVERY; BIOLOGICAL REPAIR; CHEMICAL REACTIONS; DISEASES; ELEMENTS; NONMETALS; ORGANIC COMPOUNDS; PATHOGENESIS; POPULATIONS; REPAIR

Citation Formats

Klaunig, James E., E-mail: jklauni@indiana.edu, Zemin, Wang, Xinzhu, Pu, and Shaoyu, Zhou. Oxidative stress and oxidative damage in chemical carcinogenesis. United States: N. p., 2011. Web. doi:10.1016/j.taap.2009.11.028.
Klaunig, James E., E-mail: jklauni@indiana.edu, Zemin, Wang, Xinzhu, Pu, & Shaoyu, Zhou. Oxidative stress and oxidative damage in chemical carcinogenesis. United States. https://doi.org/10.1016/j.taap.2009.11.028
Klaunig, James E., E-mail: jklauni@indiana.edu, Zemin, Wang, Xinzhu, Pu, and Shaoyu, Zhou. 2011. "Oxidative stress and oxidative damage in chemical carcinogenesis". United States. https://doi.org/10.1016/j.taap.2009.11.028.
@article{osti_21587794,
title = {Oxidative stress and oxidative damage in chemical carcinogenesis},
author = {Klaunig, James E., E-mail: jklauni@indiana.edu and Zemin, Wang and Xinzhu, Pu and Shaoyu, Zhou},
abstractNote = {Reactive oxygen species (ROS) are induced through a variety of endogenous and exogenous sources. Overwhelming of antioxidant and DNA repair mechanisms in the cell by ROS may result in oxidative stress and oxidative damage to the cell. This resulting oxidative stress can damage critical cellular macromolecules and/or modulate gene expression pathways. Cancer induction by chemical and physical agents involves a multi-step process. This process includes multiple molecular and cellular events to transform a normal cell to a malignant neoplastic cell. Oxidative damage resulting from ROS generation can participate in all stages of the cancer process. An association of ROS generation and human cancer induction has been shown. It appears that oxidative stress may both cause as well as modify the cancer process. Recently association between polymorphisms in oxidative DNA repair genes and antioxidant genes (single nucleotide polymorphisms) and human cancer susceptibility has been shown.},
doi = {10.1016/j.taap.2009.11.028},
url = {https://www.osti.gov/biblio/21587794}, journal = {Toxicology and Applied Pharmacology},
issn = {0041-008X},
number = 2,
volume = 254,
place = {United States},
year = {Fri Jul 15 00:00:00 EDT 2011},
month = {Fri Jul 15 00:00:00 EDT 2011}
}