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Title: Simultaneous {sup 68}Ga-DOTATOC-PET/MRI for IMRT Treatment Planning for Meningioma: First Experience

Abstract

Purpose: To evaluate intensity-modulated radiotherapy (IMRT) treatment planning based on simultaneous positron-emission tomography and magnetic resonance imaging (PET/MRI) of meningioma. Methods and Materials: A meningioma patient was examined prior to radiotherapy with dedicated planning computed tomography (CT), MRI, PET/CT with gallium-68-labeled DOTATOC ({sup 68}Ga-DOTATOC), and simultaneous {sup 68}Ga-DOTATOC-PET/MRI. The first gross target volume (GTV) was defined based on a combination of separate MR and {sup 68}Ga-DOTATOC-PET/CT imaging (GTV{sub PET/CT+MR}). Then, the simultaneous PET/MR images were used to delineate a second GTV (GTV{sub PET/MR}) by following exactly the same delineation strategy. After an isotropic expansion of those volumes by a 4-mm safety margin, the resulting planning target volumes (PTVs) were compared by calculating the intersection volume and the relative complements. A cross-evaluation of IMRT plans was performed, where the treatment plan created for the PTV{sub PET/CT+MR} was applied to the PET/MR-based PTV{sub PET/MR}. Results: Generally, target volumes for IMRT treatment planning did not differ between MRI plus {sup 68}Ga-DOTATOC-PET/CT and simultaneous PET/MR imaging. Only in certain regions of the GTV were differences observed. The overall volume of the PET/MR-based PTV was approximately the same as that obtained from PET/CT data. A small region of infiltrative tumor growth next to the mainmore » tumor mass was better visualized with combined PET/MR due to smaller PET voxel sizes and improved recovery. An IMRT treatment plan was optimized for the PTV{sub PET/CT+MR}. The evaluation of this plan with respect to the PTV{sub PET/MR} showed parts of the target volume that would not have received the full radiation dose after delineation of the tumor, based on simultaneous PET/MR. Conclusion: This case showed that differences in target volumes delineated on the basis of separate MR and PET/CT and simultaneous PET/MR may be observed that can have significant consequences for an effectively applied radiotherapy treatment plan.« less

Authors:
 [1]; ;  [2];  [3];  [4];  [5]; ;  [6];  [5]
  1. Section of Biomedical Physics, University Hospital for Radiation Oncology, Eberhard-Karls-Universitaet Tuebingen, Tuebingen (Germany)
  2. Department of Radiation Oncology, University Hospital for Radiation Oncology, Eberhard-Karls-Universitaet Tuebingen, Tuebingen (Germany)
  3. Department of Nuclear Medicine, University Hospital for Radiology, Eberhard-Karls-Universitaet Tuebingen, Tuebingen (Germany)
  4. Imaging Science Institute, University Hospital, Eberhard-Kars-Universitaet Tuebingen, Tuebingen (Germany)
  5. Department of Diagnostic and Interventional Radiology, University Hospital for Radiology, Eberhard-Karls-Universitaet Tuebingen, Tuebingen (Germany)
  6. Laboratory of Preclinical Imaging and Imaging Technology of the Werner Siemens-Foundation, University Hospital for Radiology, Eberhard-Karls-Universitaet Tuebingen, Tuebingen (Germany)
Publication Date:
OSTI Identifier:
21587699
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 81; Journal Issue: 1; Other Information: DOI: 10.1016/j.ijrobp.2010.10.078; PII: S0360-3016(10)03698-9; Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CENTRAL NERVOUS SYSTEM; GALLIUM 68; NEOPLASMS; NMR IMAGING; POSITRON COMPUTED TOMOGRAPHY; RADIATION DOSES; RADIOTHERAPY; SAFETY MARGINS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; DOSES; ELECTRON CAPTURE RADIOISOTOPES; EMISSION COMPUTED TOMOGRAPHY; GALLIUM ISOTOPES; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOTOPES; MEDICINE; NERVOUS SYSTEM; NUCLEAR MEDICINE; NUCLEI; ODD-ODD NUCLEI; RADIOISOTOPES; RADIOLOGY; THERAPY; TOMOGRAPHY

Citation Formats

Thorwarth, Daniela, Henke, Guido, Mueller, Arndt-Christian, Reimold, Matthias, Beyer, Thomas, Boss, Andreas, Kolb, Armin, Pichler, Bernd, and Pfannenberg, Christina. Simultaneous {sup 68}Ga-DOTATOC-PET/MRI for IMRT Treatment Planning for Meningioma: First Experience. United States: N. p., 2011. Web. doi:10.1016/j.ijrobp.2010.10.078.
Thorwarth, Daniela, Henke, Guido, Mueller, Arndt-Christian, Reimold, Matthias, Beyer, Thomas, Boss, Andreas, Kolb, Armin, Pichler, Bernd, & Pfannenberg, Christina. Simultaneous {sup 68}Ga-DOTATOC-PET/MRI for IMRT Treatment Planning for Meningioma: First Experience. United States. https://doi.org/10.1016/j.ijrobp.2010.10.078
Thorwarth, Daniela, Henke, Guido, Mueller, Arndt-Christian, Reimold, Matthias, Beyer, Thomas, Boss, Andreas, Kolb, Armin, Pichler, Bernd, and Pfannenberg, Christina. 2011. "Simultaneous {sup 68}Ga-DOTATOC-PET/MRI for IMRT Treatment Planning for Meningioma: First Experience". United States. https://doi.org/10.1016/j.ijrobp.2010.10.078.
@article{osti_21587699,
title = {Simultaneous {sup 68}Ga-DOTATOC-PET/MRI for IMRT Treatment Planning for Meningioma: First Experience},
author = {Thorwarth, Daniela and Henke, Guido and Mueller, Arndt-Christian and Reimold, Matthias and Beyer, Thomas and Boss, Andreas and Kolb, Armin and Pichler, Bernd and Pfannenberg, Christina},
abstractNote = {Purpose: To evaluate intensity-modulated radiotherapy (IMRT) treatment planning based on simultaneous positron-emission tomography and magnetic resonance imaging (PET/MRI) of meningioma. Methods and Materials: A meningioma patient was examined prior to radiotherapy with dedicated planning computed tomography (CT), MRI, PET/CT with gallium-68-labeled DOTATOC ({sup 68}Ga-DOTATOC), and simultaneous {sup 68}Ga-DOTATOC-PET/MRI. The first gross target volume (GTV) was defined based on a combination of separate MR and {sup 68}Ga-DOTATOC-PET/CT imaging (GTV{sub PET/CT+MR}). Then, the simultaneous PET/MR images were used to delineate a second GTV (GTV{sub PET/MR}) by following exactly the same delineation strategy. After an isotropic expansion of those volumes by a 4-mm safety margin, the resulting planning target volumes (PTVs) were compared by calculating the intersection volume and the relative complements. A cross-evaluation of IMRT plans was performed, where the treatment plan created for the PTV{sub PET/CT+MR} was applied to the PET/MR-based PTV{sub PET/MR}. Results: Generally, target volumes for IMRT treatment planning did not differ between MRI plus {sup 68}Ga-DOTATOC-PET/CT and simultaneous PET/MR imaging. Only in certain regions of the GTV were differences observed. The overall volume of the PET/MR-based PTV was approximately the same as that obtained from PET/CT data. A small region of infiltrative tumor growth next to the main tumor mass was better visualized with combined PET/MR due to smaller PET voxel sizes and improved recovery. An IMRT treatment plan was optimized for the PTV{sub PET/CT+MR}. The evaluation of this plan with respect to the PTV{sub PET/MR} showed parts of the target volume that would not have received the full radiation dose after delineation of the tumor, based on simultaneous PET/MR. Conclusion: This case showed that differences in target volumes delineated on the basis of separate MR and PET/CT and simultaneous PET/MR may be observed that can have significant consequences for an effectively applied radiotherapy treatment plan.},
doi = {10.1016/j.ijrobp.2010.10.078},
url = {https://www.osti.gov/biblio/21587699}, journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 1,
volume = 81,
place = {United States},
year = {Thu Sep 01 00:00:00 EDT 2011},
month = {Thu Sep 01 00:00:00 EDT 2011}
}