External-Beam Accelerated Partial Breast Irradiation Using Multiple Proton Beam Configurations

Journal Article · Mon Aug 01 00:00:00 EDT 2011 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/j.ijrobp.2010.04.052· OSTI ID:21587667

Xiaochun, Wang; Amos, Richard A; Xiaodong, Zhang; Taddei, Phillip J ^[1]; Hoffman, Karen E; Yu, Tse Kuan; Tereffe, Welela; Oh, Julia; Perkins, George H; Salehpour, Mohammad; Zhang, Sean X; Sun, Tzou Liang; Gillin, Michael; Buchholz, Thomas A; Strom, Eric A ^[1]

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1. Departments of Radiation Physics and Radiation Oncology, University of Texas, M. D. Anderson Cancer Center, Houston, TX (United States)

Purpose: To explore multiple proton beam configurations for optimizing dosimetry and minimizing uncertainties for accelerated partial breast irradiation (APBI) and to compare the dosimetry of proton with that of photon radiotherapy for treatment of the same clinical volumes. Methods and Materials: Proton treatment plans were created for 11 sequential patients treated with three-dimensional radiotherapy (3DCRT) photon APBI using passive scattering proton beams (PSPB) and were compared with clinically treated 3DCRT photon plans. Monte Carlo calculations were used to verify the accuracy of the proton dose calculation from the treatment planning system. The impact of range, motion, and setup uncertainty was evaluated with tangential vs. en face beams. Results: Compared with 3DCRT photons, the absolute reduction of the mean of V100 (the volume receiving 100% of prescription dose), V90, V75, V50, and V20 for normal breast using protons are 3.4%, 8.6%, 11.8%, 17.9%, and 23.6%, respectively. For breast skin, with the similar V90 as 3DCRT photons, the proton plan significantly reduced V75, V50, V30, and V10. The proton plan also significantly reduced the dose to the lung and heart. Dose distributions from Monte Carlo simulations demonstrated minimal deviation from the treatment planning system. The tangential beam configuration showed significantly less dose fluctuation in the chest wall region but was more vulnerable to respiratory motion than that for the en face beams. Worst-case analysis demonstrated the robustness of designed proton beams with range and patient setup uncertainties. Conclusions: APBI using multiple proton beams spares significantly more normal tissue, including nontarget breast and breast skin, than 3DCRT using photons. It is robust, considering the range and patient setup uncertainties.

• OSTI ID: 21587667
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Vol. 80, Issue 5; Other Information: DOI: 10.1016/j.ijrobp.2010.04.052; PII: S0360-3016(10)00666-8; Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0360-3016
• Country of Publication: United States
• Language: English

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PROTON BEAMS
RADIATION DOSE DISTRIBUTIONS
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