Tumor Volume and Metabolism of Prostate Cancer Determined by Proton Magnetic Resonance Spectroscopic Imaging at 3T Without Endorectal Coil Reveal Potential Clinical Implications in the Context of Radiation Oncology;Prostate cancer; Magnetic resonance spectroscopic imaging; Radiation oncology; Tumor volume; Biomarkers

Journal Article · Fri Jul 15 00:00:00 EDT 2011 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/j.ijrobp.2010.03.007· OSTI ID:21587630

Crehange, Gilles ^[1]; Parfait, Sebastien ^[2]; Liegard, Melanie ^[3]; Maingon, Philippe ^[1]; Ben Salem, Douraied ^[4]; Cochet, Alexandre ^[5]; Cormier, Luc ^[6]; Bonnetain, Franck ^[3]; Mirjolet, Celine ^[1]; Brunotte, Francois; Walker, Paul M ^[2]

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1. Department of Radiation Oncology, Centre Georges Francois Leclerc, Dijon (France)
2. Laboratoire Electronique, Informatique et Image - LE2I, Joint Research Unit (UMR) 5158, National Center For Scientific Research (CNRS), Dijon (France)
3. Department of Biostatistics, Centre Georges Francois Leclerc, Dijon (France)
4. Department of Radiology, University Hospital of Dijon, Dijon (France)
5. Department of Magnetic Resonance Spectroscopy, University Hospital of Dijon, Dijon (France)
6. Department of Urology, University Hospital of Dijon, Dijon (France)

Purpose: To determine whether a relationship exists between the tumor volume (TV) or relative choline content determined using magnetic resonance spectroscopy imaging (MRSI) at 3T and the clinical prognostic parameters for patients with localized prostate cancer (PCa). Methods and Materials: A total of 72 men (mean age, 67.8 {+-} 6.2 years) were stratified as having low-risk (n = 26), intermediate-risk (n = 24), or high-risk (n = 22) PCa. MRSI was performed at 3T using a phased-array coil. Spectra are expressed as the total choline/citrate, total choline plus creatine/citrate, and total choline plus polyamines plus creatine/citrate ratios. The mean ratio of the most pathologic voxels and the MRSI-based TV were also determined. Results: The mean values of the total choline/citrate, total choline plus creatine/citrate, and total choline plus polyamine plus creatine/citrate ratios were greater for Stage T2b or greater tumors vs. Stage T2a or less tumors: 7.53 {+-} 13.60 vs. 2.31 {+-} 5.65 (p = .018), 8.98 {+-} 14.58 vs. 2.56 {+-} 5.70 (p = .016), and 10.32 {+-} 15.47 vs. 3.55 {+-} 6.16 (p = .014), respectively. The mean MRSI-based TV for Stage T2b or greater and Stage T2a or less tumors was significantly different (2.23 {+-} 2.62 cm{sup 3} vs. 1.26 {+-} 2.06 cm{sup 3}, respectively; p = .030). This TV correlated with increased prostate-specific antigen levels (odds ratio, 1.293; p = .012). Patients with high-risk PCa had a larger TV than did the patients with intermediate-risk PCa. A similar result was found for the intermediate-risk group compared with the low-risk group (odds ratio, 1.225; p = .041). Conclusion: Biomarkers expressing the relative choline content and TV were significant parameters for the localization of PCa and could be helpful for determining the prognosis more accurately.

• OSTI ID: 21587630
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Vol. 80, Issue 4; Other Information: DOI: 10.1016/j.ijrobp.2010.03.007; PII: S0360-3016(10)00410-4; Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ANTIGENS
BIOLOGICAL MARKERS
CHOLINE
CITRATES
CREATINE
HAZARDS
MAGNETIC RESONANCE
METABOLISM
NEOPLASMS
NMR SPECTRA
PROSTATE
PROTONS
ALCOHOLS
AMINO ACIDS
AMMONIUM COMPOUNDS
BARYONS
BODY
CARBOXYLIC ACID SALTS
CARBOXYLIC ACIDS
DISEASES
DRUGS
ELEMENTARY PARTICLES
FERMIONS
GLANDS
HADRONS
HYDROXY COMPOUNDS
LIPOTROPIC FACTORS
MALE GENITALS
NUCLEONS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
QUATERNARY AMMONIUM COMPOUNDS
RESONANCE
SPECTRA