Dose-Volume Analysis of Radiation Nephropathy in Children: Preliminary Report of the Risk Consortium
- Department of Radiotherapy, University Hospital of Muenster (Germany)
- Department of Radiotherapy, University Hospital of Duesseldorf (Germany)
- Department of Radiotherapy, University Hospital of Freiburg (Germany)
- Department of Radiotherapy, University Hospital of Homburg/Saar (Germany)
- Center for Proton Radiation Therapy, Paul-Scherrer-Institute, Villigen (Switzerland)
- Department of Radiotherapy, University of Aachen (Germany)
- Department of Radiotherapy, University of Leipzig (Germany)
Purpose: To characterize kidney function in children and adolescents who had undergone radiation treatment that included parts of the kidney. Methods and Materials: Patients receiving radiotherapy during childhood or adolescence were prospectively registered in Germany's Registry for the Evaluation of Side Effects after Radiation in Childhood and Adolescence (RiSK). Detailed information was recorded regarding radiation doses at the organs at risk since 2001 all over Germany. Toxicity evaluation was performed according to standardized Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer criteria. Results: Up to May 2009, 1086 patients from 62 centers were recruited, including 126 patients (median age, 10.2 years) who underwent radiotherapy to parts of the kidneys. Maximal late toxicity (median follow-up 28.5 months in 74 patients) was characterized as Grade 0 (n = 65), 1 (n = 7) or 2 (n = 2). All patients with late effects had received potentially nephrotoxic chemotherapy. A statistically significant difference between patients with and without Grade 1 toxicity, revealing higher exposed kidney volumes in patients with toxicity, was seen for the kidney volume exposed to 20 Gy (V20; p = 0.031) and 30 Gy (V30; p = 0.003). Conclusions: Preliminary data indicate that radiation-induced kidney function impairment is rare in current pediatric multimodal treatment approaches. In the future, RiSK will be able to provide further detailed data regarding dose-volume effect relationships of radiation-associated side effects in pediatric oncology patients.
- OSTI ID:
- 21587565
- Journal Information:
- International Journal of Radiation Oncology, Biology and Physics, Vol. 80, Issue 3; Other Information: DOI: 10.1016/j.ijrobp.2010.03.021; PII: S0360-3016(10)00456-6; Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0360-3016
- Country of Publication:
- United States
- Language:
- English
Similar Records
Protons Offer Reduced Normal-Tissue Exposure for Patients Receiving Postoperative Radiotherapy for Resected Pancreatic Head Cancer
Intensity Modulated Radiation Therapy for Early-Stage Primary Gastric Diffuse Large B-Cell Lymphoma: Dosimetric Analysis, Clinical Outcome, and Quality of Life