Atmospheric-pressure plasma-jet from micronozzle array and its biological effects on living cells for cancer therapy
- Department of Electrical and Computer Engineering, Ajou University, Suwon 443-749 (Korea, Republic of)
- School of Biological Science, Seoul National University, Seoul 151-741 (Korea, Republic of)
- Convergence Plasma Research Center, National Fusion Research Institute, Daejeon 305-333 (Korea, Republic of)
- Department of Biological Sciences and Department of Molecular Science and Technology, Ajou University, Suwon 443-749 (Korea, Republic of)
We propose a plasma-jet device with a micrometer-sized nozzle array for use in a cancer therapy. Also, we show the biological effects of atmospheric-pressure plasma on living cells. Nitrogen-plasma activated a surrogate DNA damage signal transduction pathway, called the ataxia telangiectasia mutated (ATM)-checkpoint kinase 2 pathway, suggesting that the nitrogen-plasma generates DNA double-strand breaks. Phosphorylation of H2AX and p53 was detected in the plasma-treated cells, leading to apoptotic cell death. Thus, an effect for the nitrogen plasma in the control of apoptotic cell death provides insight into the how biological effects of the nitrogen-plasma can be applied to the control of cell survival, a finding with potential therapeutic implications.
- OSTI ID:
- 21518289
- Journal Information:
- Applied Physics Letters, Vol. 98, Issue 7; Other Information: DOI: 10.1063/1.3555434; (c) 2011 American Institute of Physics; ISSN 0003-6951
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
APOPTOSIS
ATMOSPHERIC PRESSURE
BIOPHYSICS
CONTROL
DNA
EQUIPMENT
NEOPLASMS
NITROGEN IONS
NOZZLES
PATIENTS
PHOSPHORYLATION
PLASMA JETS
STRAND BREAKS
THERAPY
CHARGED PARTICLES
CHEMICAL REACTIONS
DISEASES
DNA DAMAGES
IONS
MEDICINE
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PHYSICS