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Title: Cold atmospheric pressure plasma jet interactions with plasmid DNA

Abstract

The effect of a cold (<40 deg. C) radio frequency-driven atmospheric pressure plasma jet on plasmid DNA has been investigated. Gel electrophoresis was used to analyze the DNA forms post-treatment. The experimental data are fitted to a rate equation model that allows for quantitative determination of the rates of single and double strand break formation. The formation of double strand breaks correlates well with the atomic oxygen density. Taken with other measurements, this indicates that neutral components in the jet are effective in inducing double strand breaks.

Authors:
; ; ; ; ; ; ;  [1]
  1. Centre for Plasma Physics, School of Mathematics and Physics, Queen's University Belfast, University Road, Belfast BT7 1NN, Northern Ireland (United Kingdom)
Publication Date:
OSTI Identifier:
21518266
Resource Type:
Journal Article
Journal Name:
Applied Physics Letters
Additional Journal Information:
Journal Volume: 98; Journal Issue: 4; Other Information: DOI: 10.1063/1.3521502; (c) 2011 American Institute of Physics; Journal ID: ISSN 0003-6951
Country of Publication:
United States
Language:
English
Subject:
74 ATOMIC AND MOLECULAR PHYSICS; 70 PLASMA PHYSICS AND FUSION TECHNOLOGY; ATMOSPHERIC PRESSURE; COLLISIONS; DENSITY; DNA; ELECTROPHORESIS; GELS; INTERACTIONS; OXYGEN; PLASMA; PLASMA JETS; RADIOWAVE RADIATION; REACTION KINETICS; STRAND BREAKS; COLLOIDS; DISPERSIONS; DNA DAMAGES; ELECTROMAGNETIC RADIATION; ELEMENTS; KINETICS; NONMETALS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; PHYSICAL PROPERTIES; RADIATIONS

Citation Formats

O'Connell, D, Cox, L J, Hyland, W B, McMahon, S J, Reuter, S, Graham, W G, Gans, T, and Currell, F J. Cold atmospheric pressure plasma jet interactions with plasmid DNA. United States: N. p., 2011. Web. doi:10.1063/1.3521502.
O'Connell, D, Cox, L J, Hyland, W B, McMahon, S J, Reuter, S, Graham, W G, Gans, T, & Currell, F J. Cold atmospheric pressure plasma jet interactions with plasmid DNA. United States. https://doi.org/10.1063/1.3521502
O'Connell, D, Cox, L J, Hyland, W B, McMahon, S J, Reuter, S, Graham, W G, Gans, T, and Currell, F J. 2011. "Cold atmospheric pressure plasma jet interactions with plasmid DNA". United States. https://doi.org/10.1063/1.3521502.
@article{osti_21518266,
title = {Cold atmospheric pressure plasma jet interactions with plasmid DNA},
author = {O'Connell, D and Cox, L J and Hyland, W B and McMahon, S J and Reuter, S and Graham, W G and Gans, T and Currell, F J},
abstractNote = {The effect of a cold (<40 deg. C) radio frequency-driven atmospheric pressure plasma jet on plasmid DNA has been investigated. Gel electrophoresis was used to analyze the DNA forms post-treatment. The experimental data are fitted to a rate equation model that allows for quantitative determination of the rates of single and double strand break formation. The formation of double strand breaks correlates well with the atomic oxygen density. Taken with other measurements, this indicates that neutral components in the jet are effective in inducing double strand breaks.},
doi = {10.1063/1.3521502},
url = {https://www.osti.gov/biblio/21518266}, journal = {Applied Physics Letters},
issn = {0003-6951},
number = 4,
volume = 98,
place = {United States},
year = {Mon Jan 24 00:00:00 EST 2011},
month = {Mon Jan 24 00:00:00 EST 2011}
}