Atmospheric pressure cold plasma as an antifungal therapy
- College of Engineering, Peking University, Beijing 100871 (China)
- Department of Dermatology and Venereology, Peking Univ. 1st Hospital and Research Center for Medical Mycology, Peking Univ., Beijing 100034 (China)
- Department of Applied Science and Technology and Center for Microplasma Science and Technology, Saint Peter's College, Jersey City, New Jersey 07306 (United States)
A microhollow cathode based, direct-current, atmospheric pressure, He/O{sub 2} (2%) cold plasma microjet was used to inactive antifungal resistants Candida albicans, Candida krusei, and Candida glabrata in air and in water. Effective inactivation (>90%) was achieved in 10 min in air and 1 min in water. Antifungal susceptibility tests showed drastic reduction of the minimum inhibitory concentration after plasma treatment. The inactivation was attributed to the reactive oxygen species generated in plasma or in water. Hydroxyl and singlet molecular oxygen radicals were detected in plasma-water system by electron spin resonance spectroscopy. This approach proposed a promising clinical dermatology therapy.
- OSTI ID:
- 21518240
- Journal Information:
- Applied Physics Letters, Vol. 98, Issue 2; Other Information: DOI: 10.1063/1.3530434; (c) 2011 American Institute of Physics; ISSN 0003-6951
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
62 RADIOLOGY AND NUCLEAR MEDICINE
AIR
ATMOSPHERIC PRESSURE
CANDIDA
COLD PLASMA
DIRECT CURRENT
ELECTRON SPIN RESONANCE
HYDROXIDES
INACTIVATION
IONIZING RADIATIONS
OXYGEN
PARAMAGNETISM
PATIENTS
PLASMA JETS
SKIN
SKIN DISEASES
SPECTROSCOPY
THERAPY
WATER
BODY
CURRENTS
DISEASES
ELECTRIC CURRENTS
ELEMENTS
EUMYCOTA
FLUIDS
FUNGI
GASES
HYDROGEN COMPOUNDS
MAGNETIC RESONANCE
MAGNETISM
MEDICINE
MICROORGANISMS
NONMETALS
ORGANS
OXYGEN COMPOUNDS
PLANTS
PLASMA
RADIATIONS
RESONANCE
YEASTS