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Title: Dose-Response Effect of Charged Carbon Beam on Normal Rat Retina Assessed by Electroretinography

Abstract

Purpose: To compare the effects of carbon beam irradiation with those of proton beam irradiation on the physiology of the retina of rats. Methods and Materials: Eight-week-old Wister rats were used. The right eyes were irradiated with carbon beam (1, 2, 4, 8, and 16 Gy) or proton beam (4, 8, 16, and 24 Gy) with the rats under general anesthesia. Electroretinograms were recorded 1, 3, 6, and 12 months after the irradiation, and the amplitudes of the a and b waves were compared with those of control rats. Results: The amplitude of b waves was reduced more than that of a waves at lower irradiation doses with both types of irradiation. With carbon ion irradiation, the amplitudes of the b wave were significantly reduced after radiation doses of 8 and 16 Gy at 6 months and by radiation doses of 4, 8, and 16 Gy at 12 months. With proton beam irradiation, the b-wave amplitudes were significantly reduced after 16 and 24 Gy at 6 months and with doses of 8 Gy or greater at 12 months. For the maximum b-wave amplitude, a significant difference was observed in rats irradiated with carbon beams of 4 Gy or more andmore » with proton beams of 8 Gy or more at 12 months after irradiation. Conclusions: These results indicate that carbon beam irradiation is about two times more damaging than proton beam irradiation on the rat retina at the same dose.« less

Authors:
 [1];  [2]; ;  [3];  [1]; ; ;  [4]
  1. Department of Ophthalmology, Teikyo University School of Medicine, Tokyo (Japan)
  2. Department of Ophthalmology, Juntendo University Urayasu Hospital, Urayasu (Japan)
  3. Department of Ophthalmology, National Hospital Organization Chiba Medical Center, Chiba (Japan)
  4. National Institute of Radiological Sciences, Chiba (Japan)
Publication Date:
OSTI Identifier:
21499705
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 78; Journal Issue: 5; Other Information: DOI: 10.1016/j.ijrobp.2010.07.003; PII: S0360-3016(10)00901-6; Copyright (c) 2010 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; 62 RADIOLOGY AND NUCLEAR MEDICINE; CARBON IONS; DOSE-RESPONSE RELATIONSHIPS; PROTON BEAMS; RADIATION DOSES; RADIATION INJURIES; RATS; RETINA; ANIMALS; BEAMS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; CHARGED PARTICLES; DISEASES; DOSES; EYES; FACE; HEAD; INJURIES; IONS; MAMMALS; NUCLEON BEAMS; ORGANS; PARTICLE BEAMS; RADIATION EFFECTS; RODENTS; SENSE ORGANS; VERTEBRATES

Citation Formats

Mizota, Atsushi, Department of Ophthalmology, Juntendo University Urayasu Hospital, Urayasu, Tanaka, Minoru, Kubota, Mariko, Negishi, Hisanari, Watanabe, Emiko, Tsuji, Hiroshi, Miyahara, Nobuyuki, and Furusawa, Yoshiya. Dose-Response Effect of Charged Carbon Beam on Normal Rat Retina Assessed by Electroretinography. United States: N. p., 2010. Web. doi:10.1016/j.ijrobp.2010.07.003.
Mizota, Atsushi, Department of Ophthalmology, Juntendo University Urayasu Hospital, Urayasu, Tanaka, Minoru, Kubota, Mariko, Negishi, Hisanari, Watanabe, Emiko, Tsuji, Hiroshi, Miyahara, Nobuyuki, & Furusawa, Yoshiya. Dose-Response Effect of Charged Carbon Beam on Normal Rat Retina Assessed by Electroretinography. United States. https://doi.org/10.1016/j.ijrobp.2010.07.003
Mizota, Atsushi, Department of Ophthalmology, Juntendo University Urayasu Hospital, Urayasu, Tanaka, Minoru, Kubota, Mariko, Negishi, Hisanari, Watanabe, Emiko, Tsuji, Hiroshi, Miyahara, Nobuyuki, and Furusawa, Yoshiya. 2010. "Dose-Response Effect of Charged Carbon Beam on Normal Rat Retina Assessed by Electroretinography". United States. https://doi.org/10.1016/j.ijrobp.2010.07.003.
@article{osti_21499705,
title = {Dose-Response Effect of Charged Carbon Beam on Normal Rat Retina Assessed by Electroretinography},
author = {Mizota, Atsushi and Department of Ophthalmology, Juntendo University Urayasu Hospital, Urayasu and Tanaka, Minoru and Kubota, Mariko and Negishi, Hisanari and Watanabe, Emiko and Tsuji, Hiroshi and Miyahara, Nobuyuki and Furusawa, Yoshiya},
abstractNote = {Purpose: To compare the effects of carbon beam irradiation with those of proton beam irradiation on the physiology of the retina of rats. Methods and Materials: Eight-week-old Wister rats were used. The right eyes were irradiated with carbon beam (1, 2, 4, 8, and 16 Gy) or proton beam (4, 8, 16, and 24 Gy) with the rats under general anesthesia. Electroretinograms were recorded 1, 3, 6, and 12 months after the irradiation, and the amplitudes of the a and b waves were compared with those of control rats. Results: The amplitude of b waves was reduced more than that of a waves at lower irradiation doses with both types of irradiation. With carbon ion irradiation, the amplitudes of the b wave were significantly reduced after radiation doses of 8 and 16 Gy at 6 months and by radiation doses of 4, 8, and 16 Gy at 12 months. With proton beam irradiation, the b-wave amplitudes were significantly reduced after 16 and 24 Gy at 6 months and with doses of 8 Gy or greater at 12 months. For the maximum b-wave amplitude, a significant difference was observed in rats irradiated with carbon beams of 4 Gy or more and with proton beams of 8 Gy or more at 12 months after irradiation. Conclusions: These results indicate that carbon beam irradiation is about two times more damaging than proton beam irradiation on the rat retina at the same dose.},
doi = {10.1016/j.ijrobp.2010.07.003},
url = {https://www.osti.gov/biblio/21499705}, journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 5,
volume = 78,
place = {United States},
year = {Wed Dec 01 00:00:00 EST 2010},
month = {Wed Dec 01 00:00:00 EST 2010}
}