Relative Biological Effectiveness of Carbon Ions for Local Tumor Control of a Radioresistant Prostate Carcinoma in the Rat

Journal Article · Sat Jan 01 00:00:00 EST 2011 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/j.ijrobp.2010.07.1976· OSTI ID:21491561

Peschke, Peter ^[1]; Scholz, Michael ^[2]; Debus, Juergen ^[3]; Huber, Peter E ^[1]

---

1. Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center, Heidelberg (Germany)
2. Department of Biophysics, Helmholtz Center for Heavy Ion Research, Darmstadt (Germany)
3. Department of Clinical Radiology, University of Heidelberg, Heidelberg (Germany)

Purpose: To study the relative biological effectiveness (RBE) of carbon ion beams relative to X-rays for local tumor control in a syngeneic rat prostate tumor (Dunning subline R3327-AT1). Methods and Materials: A total of 198 animals with tumors in the distal thigh were treated with increasing single and split doses of either {sup 12}C ions or photons using a 20-mm spread-out Bragg peak. Endpoints of the study were local control (no tumor recurrence within 300 days) and volumetric changes after irradiation. The resulting values for D{sub 50} (dose at 50% tumor control probability) were used to determine RBE values. Results: The D{sub 50} values for single doses were 32.9 {+-} 0.9 Gy for {sup 12}C ions and 75.7 {+-} 1.6 Gy for photons. The respective values for split doses were 38.0 {+-} 2.3 Gy and 90.6 {+-} 2.3 Gy. The corresponding RBE values were 2.30 {+-} 0.08 for single and 2.38 {+-} 0.16 for split doses. The most prominent side effects were dry and moist desquamation of the skin, which disappeared within weeks. Conclusion: The study confirmed the effectiveness of carbon ion therapy for severely radioresistant tumors. For 1- and 2-fraction photon and {sup 12}C ion radiation, we have established individual D{sub 50} values for local tumor control as well as related RBE values.

• OSTI ID: 21491561
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Vol. 79, Issue 1; Other Information: DOI: 10.1016/j.ijrobp.2010.07.1976; PII: S0360-3016(10)02950-0; Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CARBON 12 BEAMS
CARCINOMAS
CONTROL
PHOTONS
PROSTATE
RADIATION DOSES
RADIOTHERAPY
RATS
RBE
ANIMALS
BEAMS
BODY
BOSONS
DISEASES
DOSES
ELEMENTARY PARTICLES
GLANDS
ION BEAMS
MALE GENITALS
MAMMALS
MASSLESS PARTICLES
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
RADIOLOGY
RODENTS
THERAPY
VERTEBRATES