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Title: Synthesis and release behavior of composites of camptothecin and layered double hydroxide

Abstract

A simple method, reconstruction of calcinated layered double hydroxides (CLDH) in an organic (ethanol)-water mixed solvent medium containing drug, was developed to intercalate partially a non-ionic and poorly water-soluble drug (camptothecin) into the gallery of layered double hydroxides (LDHs) to form the drug-LDH composites. The purpose of choosing organic-water mixed solvent is to increase remarkably the solubility of camptothecin (CPT) in the reconstruction medium. A probable morphology of CPT molecules in the gallery of LDHs is that CPT molecules arrange as monolayer with the long axis parallel to the LDH layers. The in vitro drug release from the composites was remarkably lower than that from the corresponding physical mixture, which shows these drug-inorganic composites can be used as a potential drug delivery system. - Graphical abstract: A simple method, reconstruction of calcinated LDHs in an organic-water medium containing drug, was developed to intercalate non-ionic and poorly water-soluble camptothecin into the gallery of LDHs.

Authors:
 [1];  [2];  [2]
  1. School of Medicine, Shandong University, Jinan 250100 (China)
  2. Key Laboratory for Colloid and Interface Chemistry of Education Ministry, Shandong University, Jinan 250100 (China)
Publication Date:
OSTI Identifier:
21483662
Resource Type:
Journal Article
Journal Name:
Journal of Solid State Chemistry
Additional Journal Information:
Journal Volume: 183; Journal Issue: 8; Other Information: DOI: 10.1016/j.jssc.2010.05.035; PII: S0022-4596(10)00238-0; Copyright (c) 2010 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Journal ID: ISSN 0022-4596
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; CARRIERS; CLATHRATES; DRUGS; ETHANOL; HYDROXIDES; LAYERS; MIXED SOLVENTS; MORPHOLOGY; SOLUBILITY; SYNTHESIS; WATER; ALCOHOLS; DISPERSIONS; HYDROGEN COMPOUNDS; HYDROXY COMPOUNDS; MIXTURES; ORGANIC COMPOUNDS; OXYGEN COMPOUNDS; SOLVENTS

Citation Formats

Lun, Dong, Li, Yan, Hou Wanguo, E-mail: wghou@sdu.edu.c, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, and Shaojie, Liu. Synthesis and release behavior of composites of camptothecin and layered double hydroxide. United States: N. p., 2010. Web. doi:10.1016/j.jssc.2010.05.035.
Lun, Dong, Li, Yan, Hou Wanguo, E-mail: wghou@sdu.edu.c, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, & Shaojie, Liu. Synthesis and release behavior of composites of camptothecin and layered double hydroxide. United States. https://doi.org/10.1016/j.jssc.2010.05.035
Lun, Dong, Li, Yan, Hou Wanguo, E-mail: wghou@sdu.edu.c, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, and Shaojie, Liu. 2010. "Synthesis and release behavior of composites of camptothecin and layered double hydroxide". United States. https://doi.org/10.1016/j.jssc.2010.05.035.
@article{osti_21483662,
title = {Synthesis and release behavior of composites of camptothecin and layered double hydroxide},
author = {Lun, Dong and Li, Yan and Hou Wanguo, E-mail: wghou@sdu.edu.c and College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042 and Shaojie, Liu},
abstractNote = {A simple method, reconstruction of calcinated layered double hydroxides (CLDH) in an organic (ethanol)-water mixed solvent medium containing drug, was developed to intercalate partially a non-ionic and poorly water-soluble drug (camptothecin) into the gallery of layered double hydroxides (LDHs) to form the drug-LDH composites. The purpose of choosing organic-water mixed solvent is to increase remarkably the solubility of camptothecin (CPT) in the reconstruction medium. A probable morphology of CPT molecules in the gallery of LDHs is that CPT molecules arrange as monolayer with the long axis parallel to the LDH layers. The in vitro drug release from the composites was remarkably lower than that from the corresponding physical mixture, which shows these drug-inorganic composites can be used as a potential drug delivery system. - Graphical abstract: A simple method, reconstruction of calcinated LDHs in an organic-water medium containing drug, was developed to intercalate non-ionic and poorly water-soluble camptothecin into the gallery of LDHs.},
doi = {10.1016/j.jssc.2010.05.035},
url = {https://www.osti.gov/biblio/21483662}, journal = {Journal of Solid State Chemistry},
issn = {0022-4596},
number = 8,
volume = 183,
place = {United States},
year = {Sun Aug 15 00:00:00 EDT 2010},
month = {Sun Aug 15 00:00:00 EDT 2010}
}