Nanoparticles as contrast-enhancing agents in optical coherence tomography imaging of the structural components of skin: Quantitative evaluation

Journal Article · Fri Aug 27 00:00:00 EDT 2010 · Quantum Electronics (Woodbury, N.Y.)

DOI:https://doi.org/10.1070/QE2010V040N06ABEH014294· OSTI ID:21471340

Kirillin, M Yu; Agrba, P D; Kamenskii, V A ^[1]; Sirotkina, M A; Shiryamova, M V; Zagainova, E V ^[2]

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1. Institute of Applied Physics, Russian Academy of Sciences, Nizhnii Novgorod (Russian Federation)
2. Nizhnii Novgorod State Medical Academy, Nizhnii Novgorod (Russian Federation)

This work examines the effect of gold nanoshells and titania nanoparticles on the imaging contrast of structural components of skin in optical coherence tomography (OCT). Experimental data are compared to Monte Carlo (MC) simulation results. In experiments with pig skin in vivo, the epidermis - dermis contrast is improved from 0.78 {+-} 0.03 to 0.92 {+-} 0.04 by gold nanoshells applied to the skin surface and from 0.78 {+-} 0.03 to 0.86 {+-} 0.04 by titania nanoparticles. The contrast of glands is enhanced by titania from 0.68 {+-} 0.12 to 0.84 {+-} 0.07. The highest contrast is reached 120 - 150 min after applying gold nanoshells and 160 - 200 min after applying titania. According to the MC simulation results, the contrast of inclusions increases from zero to 0.85 and 0.65, respectively. (optical tomography)

• OSTI ID: 21471340
• Journal Information: Quantum Electronics (Woodbury, N.Y.), Vol. 40, Issue 6; Other Information: DOI: 10.1070/QE2010v040n06ABEH014294; ISSN 1063-7818
• Country of Publication: United States
• Language: English

Related Subjects

77 NANOSCIENCE AND NANOTECHNOLOGY
EPIDERMIS
EXPERIMENTAL DATA
GLANDS
GOLD
IN VIVO
MONTE CARLO METHOD
NANOSTRUCTURES
SIMULATION
SURFACES
SWINE
TITANIUM OXIDES
TOMOGRAPHY
ANIMAL TISSUES
ANIMALS
BODY
CALCULATION METHODS
CHALCOGENIDES
DATA
DIAGNOSTIC TECHNIQUES
DOMESTIC ANIMALS
ELEMENTS
EPITHELIUM
INFORMATION
MAMMALS
METALS
NUMERICAL DATA
ORGANS
OXIDES
OXYGEN COMPOUNDS
SKIN
TITANIUM COMPOUNDS
TRANSITION ELEMENT COMPOUNDS
TRANSITION ELEMENTS
VERTEBRATES