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Title: Combined application of optical methods to increase the information content of optical coherent tomography in diagnostics of neoplastic processes

Abstract

A combined application of optical methods [optical coherent tomography (OCT), cross-polarisation optical coherent tomography, and fluorescence spectroscopy] is proposed for obtaining information on morphological and biochemical changes occurring in tissues in norm and pathology. It is shown that neoplastic and scar changes in esophagus can be distinguished using a combination of polarisation and standard OCT due to the difference between the depolarising properties of the tissues caused by the structural properties of collagenic fibres in stroma. It is shown that OCT combined with fluorescence spectroscopy with the use of 5-aminolevulinic acid is promising for determining the boundaries of carcinoma of the uterine cervix and vulva. It is found that the tumour boundary detected by optical methods coincides with the morphological boundary and extends beyond colposcopically determined boundary by about 2 mm. (laser biology and medicine)

Authors:
; ; ; ; ;  [1]
  1. Institute of Applied Physics, Russian Academy of Sciences, Nizhnii Novgorod (Russian Federation)
Publication Date:
OSTI Identifier:
21450534
Resource Type:
Journal Article
Journal Name:
Quantum Electronics (Woodbury, N.Y.)
Additional Journal Information:
Journal Volume: 32; Journal Issue: 11; Other Information: DOI: 10.1070/QE2002v032n11ABEH002334; Journal ID: ISSN 1063-7818
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; AMINOLEVULINIC ACID; CARCINOMAS; ESOPHAGUS; FLUORESCENCE SPECTROSCOPY; OPTICAL SYSTEMS; PATHOLOGY; POLARIZATION; TOMOGRAPHY; AMINO ACIDS; BODY; CARBOXYLIC ACIDS; DIAGNOSTIC TECHNIQUES; DIGESTIVE SYSTEM; DISEASES; EMISSION SPECTROSCOPY; NEOPLASMS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; SPECTROSCOPY

Citation Formats

Kuranov, R V, Sapozhnikova, V V, Shakhova, N M, Gelikonov, V M, Zagainova, E V, and Petrova, S A. Combined application of optical methods to increase the information content of optical coherent tomography in diagnostics of neoplastic processes. United States: N. p., 2002. Web. doi:10.1070/QE2002V032N11ABEH002334.
Kuranov, R V, Sapozhnikova, V V, Shakhova, N M, Gelikonov, V M, Zagainova, E V, & Petrova, S A. Combined application of optical methods to increase the information content of optical coherent tomography in diagnostics of neoplastic processes. United States. https://doi.org/10.1070/QE2002V032N11ABEH002334
Kuranov, R V, Sapozhnikova, V V, Shakhova, N M, Gelikonov, V M, Zagainova, E V, and Petrova, S A. 2002. "Combined application of optical methods to increase the information content of optical coherent tomography in diagnostics of neoplastic processes". United States. https://doi.org/10.1070/QE2002V032N11ABEH002334.
@article{osti_21450534,
title = {Combined application of optical methods to increase the information content of optical coherent tomography in diagnostics of neoplastic processes},
author = {Kuranov, R V and Sapozhnikova, V V and Shakhova, N M and Gelikonov, V M and Zagainova, E V and Petrova, S A},
abstractNote = {A combined application of optical methods [optical coherent tomography (OCT), cross-polarisation optical coherent tomography, and fluorescence spectroscopy] is proposed for obtaining information on morphological and biochemical changes occurring in tissues in norm and pathology. It is shown that neoplastic and scar changes in esophagus can be distinguished using a combination of polarisation and standard OCT due to the difference between the depolarising properties of the tissues caused by the structural properties of collagenic fibres in stroma. It is shown that OCT combined with fluorescence spectroscopy with the use of 5-aminolevulinic acid is promising for determining the boundaries of carcinoma of the uterine cervix and vulva. It is found that the tumour boundary detected by optical methods coincides with the morphological boundary and extends beyond colposcopically determined boundary by about 2 mm. (laser biology and medicine)},
doi = {10.1070/QE2002V032N11ABEH002334},
url = {https://www.osti.gov/biblio/21450534}, journal = {Quantum Electronics (Woodbury, N.Y.)},
issn = {1063-7818},
number = 11,
volume = 32,
place = {United States},
year = {Sat Nov 30 00:00:00 EST 2002},
month = {Sat Nov 30 00:00:00 EST 2002}
}