Effect of Intravascular Iodinated Contrast Media on Natural Course of End-Stage Renal Disease Progression in Hemodialysis Patients: A Prospective Study
- Institute for Clinical and Experimental Medicine, Department of Diagnostic and Interventional Radiology (Czech Republic)
- Charles University Hospital, Department of Radiology (Czech Republic)
- Charles University Hospital, Division of Nephrology, Department of Gerontology and Metabolism (Czech Republic)
- Central Hospital, Department of Radiology (Czech Republic)
- Fresenius Medical Care, D.C (Czech Republic)
- Charles University Hospital, Department of Gerontometabolic Medicine (Czech Republic)
- Faculty of Medicine, Department of Biostatistics (Czech Republic)
We evaluated the impact of intravascular iodinated contrast medium on residual diuresis in hemodialyzed patients. Two groups of clinically stable hemodialyzed patients with residual diuresis minimally 500 ml of urine per day were studied. The patients from the first group were given iso-osmolal contrast agent iodixanol (Visipaque, GE Healthcare, United Kingdom) in concentration of iodine 320 mg/ml with osmolality 290 mOsm/kg of water during the endovascular procedure. The second control group was followed without contrast medium administered. Residual diuresis and residual renal excretory capacity expressed as 24-h calculated creatinine clearance were evaluated in the both groups after 6 months. The evaluated group included 42 patients who were given 99.3 ml of iodixanol in average (range, 60-180 ml). The control group included 45 patients. There was no statistically significant difference found between both groups in daily volume of urine (P = 0.855) and calculated clearance of creatinine (P = 0.573). We can conclude that residual diuresis is not significantly influenced by intravascular administration of iso-osmolal iodinated contrast agent (iodixanol) in range of volume from 60 to 180 ml in comparison to natural course of urinary output and residual renal function during end-stage renal disease. This result can help the nephrologist to decide which imaging method/contrast medium to use in dialyzed patients in current practice.
- OSTI ID:
- 21429058
- Journal Information:
- Cardiovascular and Interventional Radiology, Vol. 33, Issue 1; Conference: BSIR (British Society of Interventional Radiology) 2009 annual meeting, Brighton (United Kingdom), 4-6 Nov 2009; Other Information: DOI: 10.1007/s00270-009-9715-3; Copyright (c) 2010 Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); ISSN 0174-1551
- Country of Publication:
- United States
- Language:
- English
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