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Title: Porous Gelatin Particles for Uterine Artery Embolization: An Experimental Study of Intra-Arterial Distribution, Uterine Necrosis, and Inflammation in a Porcine Model

Abstract

PurposeWe evaluated the location of porous gelatin particles (GP; Gelpart; Nippon Kayaku/Astellas, Tokyo, Japan) within the arterial vasculature and their acute effects on uterine necrosis and inflammation after uterine artery embolization (UAE) in swine.Materials and MethodsAdult nonpregnant pigs (n = 6) were allocated to either 1- (n = 3) or 2-mm GP (n = 3). Superselective and bilateral embolization of the uterine arteries was performed. All animals were killed 1 week after UAE. Macroscopic and microscopic findings, including the level of arterial occlusion and their effect on uterine necrosis and inflammation, were analyzed.ResultsAll UAE procedures were completed without severe complications. The macroscopic necrosis was seen in two animals in the 2-mm group with an extent of <50%. The location of the occluded arteries did not differ significantly between groups. The median diameters of the occluded arteries were 449 {mu}m (95% confidence interval [CI] 417-538 {mu}m) in the 1-mm GP group and 484 {mu}m (95% CI 370-560 {mu}m) in the 2-mm GP group. As for microscopic necrosis, no statistically significant difference was observed. The qualitative inflammatory reaction was significantly greater in the 2-mm GP group than in the 1-mm group (p < 0.001).ConclusionsBoth 1- and 2-mm GP occluded the arteries relevantmore » to the target diameter for UAE in porcine uterus, presumably due to the plastic deformity. Both sizes of GP were associated with limited areas of necrosis; however, evaluation of inflammatory reaction was preliminary. Further study with adequate evaluation of inflammatory reactions is suggested.« less

Authors:
 [1];  [2];  [3]; ;  [2]; ; ;  [1];  [2]; ;  [3]
  1. Iwate Medical University, Department of Radiology (Japan)
  2. Osaka University Graduate School of Medicine, Department of Diagnostic and Interventional Radiology (Japan)
  3. Osaka University Graduate School of Medicine, Department of Pathology (Japan)
Publication Date:
OSTI Identifier:
21428909
Resource Type:
Journal Article
Journal Name:
Cardiovascular and Interventional Radiology
Additional Journal Information:
Journal Volume: 33; Journal Issue: 5; Other Information: DOI: 10.1007/s00270-010-9935-6; Copyright (c) 2010 Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); Journal ID: ISSN 0174-1551
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ARTERIES; EMBOLI; GELATIN; INFLAMMATION; NECROSIS; PARTICLES; POROUS MATERIALS; SWINE; UTERUS; ANIMALS; BLOOD VESSELS; BODY; CARDIOVASCULAR SYSTEM; COLLOIDS; DISPERSIONS; DOMESTIC ANIMALS; FEMALE GENITALS; MAMMALS; MATERIALS; ORGANIC COMPOUNDS; ORGANS; PATHOLOGICAL CHANGES; PROTEINS; SYMPTOMS; VERTEBRATES

Citation Formats

Sone, Miyuki, Osuga, Keigo, Shimazu, Kohki, Higashihara, Hiroki, Nakazawa, Tetsuro, Kato, Kenichi, Tomabechi, Makiko, Ehara, Shigeru, Nakamura, Hironobu, Morii, Eiichi, and Aozasa, Katsuyuki. Porous Gelatin Particles for Uterine Artery Embolization: An Experimental Study of Intra-Arterial Distribution, Uterine Necrosis, and Inflammation in a Porcine Model. United States: N. p., 2010. Web. doi:10.1007/S00270-010-9935-6.
Sone, Miyuki, Osuga, Keigo, Shimazu, Kohki, Higashihara, Hiroki, Nakazawa, Tetsuro, Kato, Kenichi, Tomabechi, Makiko, Ehara, Shigeru, Nakamura, Hironobu, Morii, Eiichi, & Aozasa, Katsuyuki. Porous Gelatin Particles for Uterine Artery Embolization: An Experimental Study of Intra-Arterial Distribution, Uterine Necrosis, and Inflammation in a Porcine Model. United States. https://doi.org/10.1007/S00270-010-9935-6
Sone, Miyuki, Osuga, Keigo, Shimazu, Kohki, Higashihara, Hiroki, Nakazawa, Tetsuro, Kato, Kenichi, Tomabechi, Makiko, Ehara, Shigeru, Nakamura, Hironobu, Morii, Eiichi, and Aozasa, Katsuyuki. 2010. "Porous Gelatin Particles for Uterine Artery Embolization: An Experimental Study of Intra-Arterial Distribution, Uterine Necrosis, and Inflammation in a Porcine Model". United States. https://doi.org/10.1007/S00270-010-9935-6.
@article{osti_21428909,
title = {Porous Gelatin Particles for Uterine Artery Embolization: An Experimental Study of Intra-Arterial Distribution, Uterine Necrosis, and Inflammation in a Porcine Model},
author = {Sone, Miyuki and Osuga, Keigo and Shimazu, Kohki and Higashihara, Hiroki and Nakazawa, Tetsuro and Kato, Kenichi and Tomabechi, Makiko and Ehara, Shigeru and Nakamura, Hironobu and Morii, Eiichi and Aozasa, Katsuyuki},
abstractNote = {PurposeWe evaluated the location of porous gelatin particles (GP; Gelpart; Nippon Kayaku/Astellas, Tokyo, Japan) within the arterial vasculature and their acute effects on uterine necrosis and inflammation after uterine artery embolization (UAE) in swine.Materials and MethodsAdult nonpregnant pigs (n = 6) were allocated to either 1- (n = 3) or 2-mm GP (n = 3). Superselective and bilateral embolization of the uterine arteries was performed. All animals were killed 1 week after UAE. Macroscopic and microscopic findings, including the level of arterial occlusion and their effect on uterine necrosis and inflammation, were analyzed.ResultsAll UAE procedures were completed without severe complications. The macroscopic necrosis was seen in two animals in the 2-mm group with an extent of <50%. The location of the occluded arteries did not differ significantly between groups. The median diameters of the occluded arteries were 449 {mu}m (95% confidence interval [CI] 417-538 {mu}m) in the 1-mm GP group and 484 {mu}m (95% CI 370-560 {mu}m) in the 2-mm GP group. As for microscopic necrosis, no statistically significant difference was observed. The qualitative inflammatory reaction was significantly greater in the 2-mm GP group than in the 1-mm group (p < 0.001).ConclusionsBoth 1- and 2-mm GP occluded the arteries relevant to the target diameter for UAE in porcine uterus, presumably due to the plastic deformity. Both sizes of GP were associated with limited areas of necrosis; however, evaluation of inflammatory reaction was preliminary. Further study with adequate evaluation of inflammatory reactions is suggested.},
doi = {10.1007/S00270-010-9935-6},
url = {https://www.osti.gov/biblio/21428909}, journal = {Cardiovascular and Interventional Radiology},
issn = {0174-1551},
number = 5,
volume = 33,
place = {United States},
year = {Fri Oct 15 00:00:00 EDT 2010},
month = {Fri Oct 15 00:00:00 EDT 2010}
}