Portal Vein Embolization with Radiolabeled Polyvinyl Alcohol Particles in a Swine Model: Hepatic Distribution and Implications for Pancreatic Islet Cell Transplantation

Journal Article · Fri May 15 00:00:00 EDT 2009 · Cardiovascular and Interventional Radiology

DOI:https://doi.org/10.1007/S00270-009-9544-4· OSTI ID:21428529

Mercer, John R ^[1]; Al-Saif, Faisal; Molinari, Michele ^[2]; Ashforth, Robert A ^[3]; Rajotte, Ray V ^[4]; Conner-Spady, Barbara ^[3]; Shapiro, A M. James ^[5]

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1. University of Alberta, Department of Oncologic Imaging, Faculty of Medicine (Canada)
2. University of Alberta Hospital, Department of Surgery (Canada)
3. University of Alberta, Department of Radiology and Diagnostic Imaging, Faculty of Medicine, Walter Mackenzie Health Sciences Center (Canada)
4. University of Alberta, Surgical-Medical Research Institute (Canada)
5. University of Alberta, Clinical Islet Transplant Program (Canada)

The distribution of radiolabeled polyvinyl alcohol microspheres (PVAMs) when infused into the portal vein of domestic swine was investigated, with the purpose of assessing implications for pancreatic islet cell transplantation. PVAMs measuring 100-300 {mu}m (Contour SE) and labeled with {sup 99m}Tc were infused into the main portal vein of 12 swine, with intermittent portal venous pressure measurements. The infusion catheter was introduced antegradely via direct or indirect cannulation of the portal vein. The liver was subsequently divided into anatomical segments. Radioactivity (decay corrected) was measured for {sup 99m}Tc microsphere synthesis, dose preparation, gross organ activities, tissue samples, and blood. Particulate labeling, catheter positioning, and infusion were successful in all cases. The number of particles used was (185,000 {+-} 24,000) with a volume of 1 ml. Mean portal pressure at 5 min was significantly higher than baseline, but without a significant difference at 15 min. Extrahepatic tissue and serum radioactivity was negligible. A significant difference in number of radioactive particles per gram was detected between segments 6/7 and segments 5/8. Intrasegmental activity was analyzed, and for segments 2/3 a significant difference in the percentage dose per gram across samples was demonstrated (P = 0.001). Effective and stable radiolabeling of PVAMs with {sup 99m}Tc-sulfur colloid was demonstrated. Portal venous infusion of 100- to 300-{mu}m particles showed entrapment in the sinusoidal hepatic system with transient portal pressure elevation. Preferential embolization into the right lateral and posterior segments occurs, suggesting that flow dynamics/catheter tip position plays a role in particle distribution.

• OSTI ID: 21428529
• Journal Information: Cardiovascular and Interventional Radiology, Vol. 32, Issue 3; Other Information: DOI: 10.1007/s00270-009-9544-4; Copyright (c) 2009 Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); Article Copyright (c) 2009 Springer Science+Business Media, LLC; ISSN 0174-1551
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
INFUSION
LABELLING
LIVER
MICROSPHERES
PANCREAS
PARTICLES
POSITIONING
PVA
RADIOACTIVITY
SWINE
TECHNETIUM 99
TUBES
VEINS
ALCOHOLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
DIGESTIVE SYSTEM
DOMESTIC ANIMALS
ENDOCRINE GLANDS
GLANDS
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
INTAKE
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC POLYMERS
ORGANS
POLYMERS
POLYVINYLS
RADIOISOTOPES
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES