Radiographic Response to Yttrium-90 Radioembolization in Anterior Versus Posterior Liver Segments

Journal Article · Sat Nov 15 00:00:00 EST 2008 · Cardiovascular and Interventional Radiology

DOI:https://doi.org/10.1007/S00270-008-9348-Y· OSTI ID:21426342

Ibrahim, Saad M; Lewandowski, Robert J; Ryu, Robert K; Sato, Kent T; Gates, Vanessa L ^[1]; Mulcahy, Mary F ^[2]; Kulik, Laura ^[3]; Larson, Andrew C ^[4]; Omary, Reed A; Salem, Riad ^[1]

---

1. Northwestern University, Department of Radiology, Section of Interventional Radiology (United States)
2. Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Department of Medicine, Division of Hematology and Oncology (United States)
3. Northwestern University, Department of Medicine, Division of Hepatology (United States)
4. Northwestern University, Department of Biomedical Engineering (United States)

The purpose of our study was to determine if preferential radiographic tumor response occurs in tumors located in posterior versus anterior liver segments following radioembolization with yttrium-90 glass microspheres. One hundred thirty-seven patients with chemorefractory liver metastases of various primaries were treated with yttrium-90 glass microspheres. Of these, a subset analysis was performed on 89 patients who underwent 101 whole-right-lobe infusions to liver segments V, VI, VII, and VIII. Pre- and posttreatment imaging included either triphasic contrast material-enhanced CT or gadolinium-enhanced MRI. Responses to treatment were compared in anterior versus posterior right lobe lesions using both RECIST and WHO criteria. Statistical comparative studies were conducted in 42 patients with both anterior and posterior segment lesions using the paired-sample t-test. Pearson correlation was used to determine the relationship between pretreatment tumor size and posttreatment tumor response. Median administered activity, delivered radiation dose, and treatment volume were 2.3 GBq, 118.2 Gy, and 1,072 cm{sup 3}, respectively. Differences between the pretreatment tumor size of anterior and posterior liver segments were not statistically significant (p = 0.7981). Differences in tumor response between anterior and posterior liver segments were not statistically significant using WHO criteria (p = 0.8557). A statistically significant correlation did not exist between pretreatment tumor size and posttreatment tumor response (r = 0.0554, p = 0.4434). On imaging follow-up using WHO criteria, for anterior and posterior regions of the liver, (1) response rates were 50% (PR = 50%) and 45% (CR = 9%, PR = 36%), and (2) mean changes in tumor size were -41% and -40%. In conclusion, this study did not find evidence of preferential radiographic tumor response in posterior versus anterior liver segments treated with yttrium-90 glass microspheres.

• OSTI ID: 21426342
• Journal Information: Cardiovascular and Interventional Radiology, Vol. 31, Issue 6; Other Information: DOI: 10.1007/s00270-008-9348-y; Copyright (c) 2008 Springer Science+Business Media, LLC; ISSN 0174-1551
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
GLASS
INFUSION
LIVER
METASTASES
MICROSPHERES
NEOPLASMS
NMR IMAGING
RADIATION DOSES
YTTRIUM 90
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
DOSES
GLANDS
HOURS LIVING RADIOISOTOPES
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NUCLEI
ODD-ODD NUCLEI
ORGANS
RADIOISOTOPES
YTTRIUM ISOTOPES