Bent Laue X-ray Fluorescence Imaging of Manganese in Biological Tissues--Preliminary Results

Journal Article · Wed Jun 23 00:00:00 EDT 2010 · AIP Conference Proceedings

DOI:https://doi.org/10.1063/1.3463239· OSTI ID:21415243

Ying, Zhu; Honglin, Zhang ^[1]; Bewer, Brian ^[2]; Nichol, Helen; Chapman, Dean ^[3]; Thomlinson, Bill ^[4]

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1. Biomedical Engineering, University of Saskatchewan, 57 Campus Drive, Saskatoon, SK S7N 5A9 (Canada)
2. Physics and Engineering Physics, University of Saskatchewan, 116 Science Place, Saskatoon, SK S7N 5E2 (Canada)
3. Anatomy and Cell Biology, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK S7N 5E5 (Canada)
4. Office of the Vice President Research, University of Saskatchewan, 121 Research Drive, Saskatoon, SK S7N 1K2 (Canada)

Manganese (Mn) is not abundant in human brain tissue, but it is recognized as a neurotoxin. The symptoms of manganese intoxication are similar to Parkinson's disease (PD), but the link between environmental, occupational or dietary Mn exposure and PD in humans is not well established. X-ray Absorption Spectroscopy (XAS) and in particular X-ray fluorescence can provide precise information on the distribution, concentration and chemical form of metals. However the scattered radiation and fluorescence from the adjacent abundant element, iron (Fe), may interfere with and limit the ability to detect ultra-dilute Mn. A bent Laue analyzer based Mn fluorescence detection system has been designed and fabricated to improve elemental specificity in XAS imaging. This bent Laue analyzer of logarithmic spiral shape placed upstream of an energy discriminating detector should improve the energy resolution from hundreds of eV to several eV. The bent Laue detection system was validated by imaging Mn fluorescence from Mn foils, gelatin calibration samples and adult Drosophila at the Hard X-ray MicroAnalysis (HXMA) beamline at the Canadian Light Source (CLS). Optimization of the design parameters, fabrication procedures and preliminary experimental results are presented along with future plans.

• OSTI ID: 21415243
• Journal Information: AIP Conference Proceedings, Vol. 1234, Issue 1; Conference: SRI 2009: 10. international conference on radiation instrumentation, Melbourne (Australia), 27 Sep - 2 Oct 2009; Other Information: DOI: 10.1063/1.3463239; (c) 2010 American Institute of Physics; ISSN 0094-243X
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ABSORPTION SPECTROSCOPY
ADULTS
BRAIN
CALIBRATION
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
DROSOPHILA
ENERGY RESOLUTION
FLUORESCENCE
HARD X RADIATION
LIGHT SOURCES
MANGANESE
NERVOUS SYSTEM DISEASES
REFLECTIVITY
SPECIFICITY
SYMPTOMS
SYNCHROTRON RADIATION
X-RAY SPECTRA
X-RAY SPECTROSCOPY
AGE GROUPS
ANIMALS
ARTHROPODS
BODY
BREMSSTRAHLUNG
CENTRAL NERVOUS SYSTEM
DIPTERA
DISEASES
ELECTROMAGNETIC RADIATION
ELEMENTS
EMISSION
FLIES
FRUIT FLIES
INSECTS
INVERTEBRATES
IONIZING RADIATIONS
LUMINESCENCE
METALS
NERVOUS SYSTEM
OPTICAL PROPERTIES
ORGANS
PHOTON EMISSION
PHYSICAL PROPERTIES
RADIATION SOURCES
RADIATIONS
RESOLUTION
SPECTRA
SPECTROSCOPY
SURFACE PROPERTIES
TRANSITION ELEMENTS
X RADIATION