Progress In The Development Of A Tomographic SPECT System For Online Dosimetry In BNCT

Journal Article · Wed Aug 04 00:00:00 EDT 2010 · AIP Conference Proceedings

DOI:https://doi.org/10.1063/1.3480218· OSTI ID:21410824

Minsky, D M; Kreiner, A J ^[1]; Valda, A; Burlon, A A ^[1]; Green, S; Wojnecki, C ^[2]; Ghani, Z ^[3]

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1. Gerencia de Investigacion y Aplicaciones, CAC, CNEA, Av. Gral. Paz 1499 (B1650KNA), San Martin, Prov. Bs. As. (Argentina)
2. School of Physscs and Astronomy, University of Birmingham, B15 2TT (United Kingdom)
3. Department of Medical Physics, University Hospital Birmingham, Birmingham, B15 2TH (United Kingdom)

In boron neutron capture therapy (BNCT) the delivered dose to the patient depends both on the neutron beam characteristics and on the {sup 10}B body distribution which, in turn, is governed by the tumor specificity of the {sup 10}B drug-carrier. BNCT dosimetry is a complex matter due to the several interactions that neutrons can undergo with the different nuclei present in tissue. However the boron capture reaction {sup 10}B(n,{alpha}){sup 7}Li accounts for about 80 % of the total dose in a tumor with 40 ppm in {sup 10}B concentration. Present dosimetric methods are indirect, based on drug biodistribution statistical data and subjected to inter and intra-patient variability. In order to overcome the consequences of the concomitant high dosimetric uncertainties, we propose a SPECT (Single Photon Emission Tomography) approach based on the detection of the prompt gamma-ray (478 keV) emitted in 94 % of the cases from {sup 7}Li. For this purpose we designed, built and tested a prototype based on LaBr{sub 3}(Ce) scintillators. Measurements on a head and tumor phantom were performed in the accelerator-based BNCT facility of the University of Birmingham (UK). They result in the first tomographic image of the 10B capture distribution obtained in a BNCT facility.

• OSTI ID: 21410824
• Journal Information: AIP Conference Proceedings, Vol. 1265, Issue 1; Conference: 8. Latin American symposium on nuclear physics and applications, Santiago (Chile), 15-19 Dec 2009; Other Information: DOI: 10.1063/1.3480218; (c) 2010 American Institute of Physics; ISSN 0094-243X
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ACCELERATORS
BORON
BORON 10
DISTRIBUTION
DOSIMETRY
GAMMA RADIATION
INTERACTIONS
KEV RANGE 100-1000
LANTHANUM BROMIDES
LITHIUM 7
MONTE CARLO METHOD
NEOPLASMS
NEUTRON BEAMS
NEUTRON CAPTURE THERAPY
NEUTRONS
PHOTON EMISSION
RADIATION DOSES
RADIATION PROTECTION
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
SPECIFICITY
BARYONS
BEAMS
BORON ISOTOPES
BROMIDES
BROMINE COMPOUNDS
CALCULATION METHODS
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
DOSES
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
ELEMENTS
EMISSION
EMISSION COMPUTED TOMOGRAPHY
ENERGY RANGE
FERMIONS
HADRONS
HALIDES
HALOGEN COMPOUNDS
IONIZING RADIATIONS
ISOTOPES
KEV RANGE
LANTHANUM COMPOUNDS
LIGHT NUCLEI
LITHIUM ISOTOPES
MEDICINE
NEUTRON THERAPY
NUCLEAR MEDICINE
NUCLEI
NUCLEON BEAMS
NUCLEONS
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
PARTICLE BEAMS
RADIATIONS
RADIOLOGY
RADIOTHERAPY
RARE EARTH COMPOUNDS
SEMIMETALS
STABLE ISOTOPES
THERAPY
TOMOGRAPHY