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Title: Radiation-Associated Kidney Injury

Abstract

The kidneys are the dose-limiting organs for radiotherapy to upper abdominal cancers and during total body irradiation. The incidence of radiotherapy-associated kidney injury is likely underreported owing to its long latency and because the toxicity is often attributed to more common causes of kidney injury. The pathophysiology of radiation injury is poorly understood. Its presentation can be acute and irreversible or subtle, with a gradual progressive dysfunction over years. A variety of dose and volume parameters have been associated with renal toxicity and are reviewed to provide treatment guidelines. The available predictive models are suboptimal and require validation. Mitigation of radiation nephropathy with angiotensin-converting enzyme inhibitors and other compounds has been shown in animal models and, more recently, in patients.

Authors:
 [1];  [2];  [3];  [1];  [4]; ;  [5];  [6]
  1. Department of Radiation Oncology, University of Colorado, Denver, CO (United States)
  2. Department of Radiology, Division of Radiation Oncology, Baylor College of Medicine and Methodist Hospital, Houston, TX (United States)
  3. Department of Radiation Oncology, Duke University Medical Center, Durham, NC (United States)
  4. Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI (United States)
  5. Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI (United States)
  6. Department of Radiation Oncology, City of Hope Medical Center and Beckman Research Institute, Duarte, CA (United States)
Publication Date:
OSTI Identifier:
21372138
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 76; Journal Issue: 3; Other Information: DOI: 10.1016/j.ijrobp.2009.02.089; PII: S0360-3016(09)03282-9; Copyright (c) 2010 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ANGIOTENSIN; ENZYME INHIBITORS; KIDNEYS; MITIGATION; NEOPLASMS; RADIATION DOSES; RADIATION INJURIES; RADIOTHERAPY; TOXICITY; WHOLE-BODY IRRADIATION; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; CARDIOVASCULAR AGENTS; DISEASES; DOSES; DRUGS; EXTERNAL IRRADIATION; GLOBULINS; INJURIES; IRRADIATION; MEDICINE; NUCLEAR MEDICINE; ORGANIC COMPOUNDS; ORGANS; PROTEINS; RADIATION EFFECTS; RADIOLOGY; THERAPY; VASOCONSTRICTORS

Citation Formats

Dawson, Laura A., E-mail: laura.dawson@rmp.uhn.on.c, Kavanagh, Brian D, Paulino, Arnold C, Das, Shiva K, Miften, Moyed, Li, X Allen, Pan, Charlie, Ten Haken, Randall K, and Schultheiss, Timothy E. Radiation-Associated Kidney Injury. United States: N. p., 2010. Web. doi:10.1016/j.ijrobp.2009.02.089.
Dawson, Laura A., E-mail: laura.dawson@rmp.uhn.on.c, Kavanagh, Brian D, Paulino, Arnold C, Das, Shiva K, Miften, Moyed, Li, X Allen, Pan, Charlie, Ten Haken, Randall K, & Schultheiss, Timothy E. Radiation-Associated Kidney Injury. United States. https://doi.org/10.1016/j.ijrobp.2009.02.089
Dawson, Laura A., E-mail: laura.dawson@rmp.uhn.on.c, Kavanagh, Brian D, Paulino, Arnold C, Das, Shiva K, Miften, Moyed, Li, X Allen, Pan, Charlie, Ten Haken, Randall K, and Schultheiss, Timothy E. 2010. "Radiation-Associated Kidney Injury". United States. https://doi.org/10.1016/j.ijrobp.2009.02.089.
@article{osti_21372138,
title = {Radiation-Associated Kidney Injury},
author = {Dawson, Laura A., E-mail: laura.dawson@rmp.uhn.on.c and Kavanagh, Brian D and Paulino, Arnold C and Das, Shiva K and Miften, Moyed and Li, X Allen and Pan, Charlie and Ten Haken, Randall K and Schultheiss, Timothy E},
abstractNote = {The kidneys are the dose-limiting organs for radiotherapy to upper abdominal cancers and during total body irradiation. The incidence of radiotherapy-associated kidney injury is likely underreported owing to its long latency and because the toxicity is often attributed to more common causes of kidney injury. The pathophysiology of radiation injury is poorly understood. Its presentation can be acute and irreversible or subtle, with a gradual progressive dysfunction over years. A variety of dose and volume parameters have been associated with renal toxicity and are reviewed to provide treatment guidelines. The available predictive models are suboptimal and require validation. Mitigation of radiation nephropathy with angiotensin-converting enzyme inhibitors and other compounds has been shown in animal models and, more recently, in patients.},
doi = {10.1016/j.ijrobp.2009.02.089},
url = {https://www.osti.gov/biblio/21372138}, journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 3,
volume = 76,
place = {United States},
year = {Mon Mar 01 00:00:00 EST 2010},
month = {Mon Mar 01 00:00:00 EST 2010}
}